The CYP2 family are part of the microsomal drug metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances. CYP2B1 and CYP2B2 are the major phenobarbital-inducible rat hepatic cytochromes P450s. This reagent was created through a research collaboration between Cancer Research UK and […]
| Inventor | Institute |
|---|---|
| Roland Wolf | Syngenta Crop |
| Cat. #: | 151064 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Tissue-specific biology;Cell signaling and signal transduction;Metabolism |
| Application: | ELISA ; IP ; WB |
| Target: | Cytochromes P450 2B1, 2B2, CYP2B1, CYP2B2 |
| Reactivity: | Mouse ; Rat |
| Clone: | b/e3 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | The CYP2 family are part of the microsomal drug metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances. CYP2B1 and CYP2B2 are the major phenobarbital-inducible rat hepatic cytochromes P450s. This reagent was created through a research collaboration between Cancer Research UK and Syngenta Crop Protection AG. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 52 kDa |
| Immunogen: | Rat liver cytochromes p450 2B1 and 2B2 |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | The CYP2 family are part of the microsomal drug metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances. CYP2B1 and CYP2B2 are the major phenobarbital-inducible rat hepatic cytochromes P450s. This reagent was created through a research collaboration between Cancer Research UK and Syngenta Crop Protection AG. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.84 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -20° C |
| Shipping conditions: | Dry ice |
| References: |
Chanyshev et al. 2020. Toxicol Mech Methods. 30(8):562-569. PMID: 32508177. Rencurel et al. 2005. J Biol Chem. 280(6):4367-73. PMID: 15572372. AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line. Forrester et al. 1992. Biochem J. 281 ( Pt 2):359-68. PMID: 1736885. Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics. |
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