A polyclonal antibody for HSPB1p15 also known as HSP27p15.
| Inventor | Institute |
|---|---|
| Roy Quinlan | University of Durham |
| Cat. #: | 162211 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology |
| Application: | WB |
| Target: | human heat shock protein 27 phosphorylated at site 15, HSP27p15; mouse heat shock protein 27 phosphorylated at site 15, HSP27p15 |
| Reactivity: | Human |
| Class: | Polyclonal |
| Primary citation: | P A Eyers, et al. 1999. FEBS Lett. 21;451(2):191-6. PMID: 10371163 |
| Alternate name: | HSPB1p15 ; HSP27p15 |
|---|---|
| Product description: | A polyclonal antibody for HSPB1p15 also known as HSP27p15. This antibody targets HSPB1 (HSP27) a small heat shock protein which is involved in TP53 turnover, steroid receptor maturation, cytoskeletal dynamics, regulation of proteostasis and apoptosis. This antibody recognises HSPB1 when phosphorylated at serine 15. Phosphorylation of HSP27 can cause conformational change in the tertiary structure resulting in decreased oligomeric size. |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Molecular weight: | 27kDa, 205 residues |
| Immunogen: | peptide crosslinked to KLH |
| Target background: | Hsp27 is an ATP-independent molecular chaperone with well-described tumorigenic and metastatic roles, characterized by its dynamic phosphorylation leading to heterogeneous oligomerization under different conditions such as stress |
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| Format: | Liquid |
|---|---|
| Concentration: | 1mg/ml |
| Storage buffer: | Serum plus azide (0.02%) |
| Storage conditions: | -80° C |
| Shipping conditions: | Dry ice |
| References: |
P A Eyers, et al. 1999. FEBS Lett. 21 451(2):191-6. PMID: 10371163 |
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