pJEK21 Gamma-Synuclein Vector

pJEK21 is a derivative of pET15b with the open reading frame encoding the human gamma-synuclein (Îł-synuclein) cloned in via the NdeI and BamHI restriction sites. In this construct Îł-synuclein is expressed as a fusion protein with an N-terminal six His tag.

Contributors

Inventor Institute
Dr Fiona Benson Lancaster University
Cat. #: 152050
Research Fields: Neurobiology
Product description: pJEK21 is a derivative of pET15b with the open reading frame encoding the human gamma-synuclein (Îł-synuclein) cloned in via the NdeI and BamHI restriction sites. In this construct Îł-synuclein is expressed as a fusion protein with an N-terminal six His tag.
Additional notes: Gamma synuclein is structurally related to alpha-synuclein. Due to these structural similarities, gamma-synuclein can also aggregate in vitro and in vivo. This aggregation is believed to be a crucial trigger of neurodegeneration in alpha-synucleinopathies. Motor neurones express high levels of gamma-synuclein, with the protein highly abundant in their axons, where it might affect organisation of axonal cytoskeleton.
Application notes: pJEK21 is a derivative of pET15b with the open reading frame encoding the human gamma-synuclein (γ-synuclein) cloned in via the NdeI and BamHI restriction sites. In this construct γ-synuclein is expressed as a fusion protein with an N-terminal six His tag.

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