#152050

pJEK21 Gamma-Synuclein Vector

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Cat. #152050

pJEK21 Gamma-Synuclein Vector

Cat. #: 152050

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Contributor

Inventor: Dr Fiona Benson

Institute: Lancaster University

Tool Details
Application Details

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: pJEK21 Gamma-Synuclein Vector
  • Research fields: Neurobiology
  • Description: pJEK21 is a derivative of pET15b with the open reading frame encoding the human gamma-synuclein (Îł-synuclein) cloned in via the NdeI and BamHI restriction sites. In this construct Îł-synuclein is expressed as a fusion protein with an N-terminal six His tag.
  • Additional notes: Gamma synuclein is structurally related to alpha-synuclein. Due to these structural similarities, gamma-synuclein can also aggregate in vitro and in vivo. This aggregation is believed to be a crucial trigger of neurodegeneration in alpha-synucleinopathies. Motor neurones express high levels of gamma-synuclein, with the protein highly abundant in their axons, where it might affect organisation of axonal cytoskeleton.

Application Details

  • Application notes: pJEK21 is a derivative of pET15b with the open reading frame encoding the human gamma-synuclein (γ-synuclein) cloned in via the NdeI and BamHI restriction sites. In this construct γ-synuclein is expressed as a fusion protein with an N-terminal six His tag.