Cat. #152049
pJEK11 Beta-Synuclein Vector
Cat. #: 152049
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This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Dr Fiona Benson
Institute: Lancaster University
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: pJEK11 Beta-Synuclein Vector
- Research fields: Neurobiology
- Description: pJEK11 is a derivative of pET15b with the open reading frame encoding the human beta-synuclein (ÄÂĂÂ-synuclein) cloned in via the NdeI and BamHI restriction sites. In this construct ÄÂĂÂ-synuclein is expressed as a fusion protein with an N-terminal six His tag.
- Additional notes: Beta-synuclein is an abundant pre-synaptic phosphoprotein that is found in the brain and is homolgous to alpha-synuclein. Beta-synuclein is distinct from alha-synuclein in that it lacks the majority of the hydrophobic non-amyloid-beta component of the Alzeheimer's disease amyloid region. Due to this beta-synuclein is less likely to form insoluble aggregates when compared to alpha-synuclein. It is thought that beta-synuclein may have a protective role against alpha-synucleinopathies. Beta-synuclein is an acidic, neuronal protein considered to be a non-amyloidogenic homolog of alpha-synuclein. It has been postulated that beta-synuclein could act as a physiological inhibitor of α-synuclein aggregation and thus protect the central nervous system from the neurotoxic effects of alpha-synuclein
Application Details
- Application notes: pJEK11 is a derivative of pET15b with the open reading frame encoding the human beta-synuclein (β-synuclein) cloned in via the NdeI and BamHI restriction sites. In this construct β-synuclein is expressed as a fusion protein with an N-terminal six His tag.
