pSIEW-RUNX1-EVI1 Vector

A protein that in humans is encoded by the RUNX1 gene, that regulates the differentiation of hematopoietic stem cells into mature blood cells and plays a major role in the development of the neurons that transmit pain.

Contributors

Inventor Institute
Constanze Bonifer University of Birmingham
SKU: 153538
Product description: Runt-related transcription factor 1, a protein that in humans is encoded by the RUNX1 gene, that regulates the differentiation of hematopoietic stem cells into mature blood cells and plays a major role in the development of the neurons that transmit pain. It belongs to the RUNX family of genes also known as core binding factor-a, and RUNX proteins form heterodimeric complexes with these confering increased DNA binding and stability. Chromosomal translocations involving RUNX1 are associated with several types of leukemia including M2 Acute myeloid leukaemia and DNA mutations are implicated in cases of breast cancer.
Alternate name: Runt Related Transcription Factor 1, RUXN1, AML1, AML1-EVI-1, AMLCR1, CBF2alpha, CBFA2, EVI-1, PEBP2aB, PEBP2alpha, acute myeloid leukemia 1 protein, core-binding factor subunit alpha-2
Cat. #: 153538
Tool sub type: pSIEW
Research Fields: Cancer; Cell signaling and signal transduction; Genetics
Target: RUNX1-EVI1 (chimeric gene)
Backbone size without insert: 14400
Bacterial resistance: Ampicillin
Shipping conditions: Dry Ice
References:

Maki et al. 2008. Cancer Sci. 99(10):1878-83. PMID: 19016745.

Role of the RUNX1-EVI1 fusion gene in leukemogenesis.

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