Trex1 -/- Mouse

Model for the human recessive autoimmune disease Aicardi-Goutieres syndrome; potential use for testing of therapeutic agents; identifies a novel immune pathway. Trex1 KO mouse

Contributors

Inventor Institute
Tomas Lindahl Cancer Research UK, London Research Institute: Clare Hall Laboratories
SKU: 151578
Product description: Model for the human recessive autoimmune disease Aicardi-Goutieres syndrome; potential use for testing of therapeutic agents; identifies a novel immune pathway. Trex1 KO mouse
Conditional: No
CRISPR: Yes
Production details: Standard gene-targeting in ES cells using a genomic DNA construct flanking the Trex1 locus in which amino acids 103 to 207 of the Trex1 ORF were replaced by a neomycin resistance gene/polyA signal.
Cat. #: 151578
Target: TREX1
Disease: Antiviral-like autoimmunity
Model: Knock-Out
Zygosity: Homozygous
Phenotype: Autoimmunity manifested as inflammatory myocarditis / reduced lifespan
Shipping conditions: Embryo/Spermatoza- Dry Ice
References:

Yang et al. 2007. Cell. 131(5):873-86. PMID: 18045533.

Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease.

Morita et al. 2004. Mol Cell Biol. 24(15):6719-27. PMID: 15254239.

Gene-targeted mice lacking the Trex1 (DNase III) 3'–>5' DNA exonuclease develop inflammatory myocarditis.

Citations And Reviews

Related Tools for Mouse models

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151558 MEF Trex1 KO Cell Line Key Info View Tool

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