TAM1 cell line

The cells also exhibit an increased expression of Protein Kinase C alpha (PKCa), which is an important player in tamoxifen resistant breast cancer.

Contributors

Inventor Institute
Debra Tonetti University of Illinois Chicago
SKU: 156373
Product description: Approximately 70% of breast cancer patients have estrogen receptor positive (ER+) tumors. The selective estrogen receptor modulator (SERM), tamoxifen, and aromatase inhibitors (AIs) represent first-line treatment for ER+ patients however, up to 50% of patients either do not respond or acquire resistance within 5 years of treatment. The MCF-7/TAM1 cell line shows an endogenous resistance to tamoxifen. The cells also exhibit an increased expression of Protein Kinase C alpha (PKCa), which is an important player in tamoxifen resistant breast cancer.
Alternate name: MCF7
Additional notes: Engineered to over-express TAM1, which in turn causes over expression of PKCa.
Parental cell line: MCF-7
Disease: Cancer
Cat. #: 156373
Tool sub type: Continuous
Unit size: 1×10^6 cells / vial
Research Fields: Cancer;Drug development
Organism: Human
Tissue: Breast
Model: Cancer Model
Cancer Types In Detail: Breast cancer;Tamoxifen Resistance
Format: Frozen
Shipping conditions: Dry ice
References:

Xiong et al. 2017. J Med Chem. 60(4):1325-1342. PMID: 28117994.

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