Epithelial ovarian cancer cell lines spontaneously derived from high-grade serious ascites. Patient harbored BRCA1:IVS14-1G>T mutation
| Inventor | Institute |
|---|---|
| Anne-Marie Mes-Masson and Diane Provencher | Centre Hospitalier de Luniversité de Montréal |
| SKU: | 161788 |
|---|---|
| Product description: | Epithelial ovarian cancer cell lines spontaneously derived from high-grade serious ascites. Patient harbored BRCA1:IVS14-1G>T mutation |
| Alternate name: | OV-4485 |
| Gender: | Female |
| CRISPR: | No |
| Production details: | Established from the cellular fraction of ascites collected by centrifugation. The cell lines were then maintained for 40 days in OSE with medium replaced weekly. |
| Additional notes: | Patient 4485 was age 55 at diagnosis, BRCA hereditary status was BRCA1(+), and no prior personal history of cancer. Patient received Carboplatin/taxol, interval sugery, and was later in a clinical trial: maintenance sorafenib vs placebo trial. |
| Cellosaurus ID: | CVCL_9T21 |
| Receptors of note: | No |
| Cat. #: | 161788 |
|---|---|
| Research Fields: | Cancer |
| Organism: | Human |
| Tissue: | Derived from ascites |
| Gender: | Female |
| Morphology: | Formed loosely compact spheroids with irregular margins |
| Growth properties: | Adherent |
| Primary citation: | Fleury et al. 2015. Genes & Cancer. 6(9-10):378-398. PMID: 26622941 |
| Shipping conditions: | Dry Ice |
|---|---|
| Growth medium: | OSE medium contains 10% FBS, 0.5ug/mL amphotericin B and 50 ug/mL gentamicin |
| Atmosphere: | Low oxygen conditions of 7% O2 and 5% CO2 |
| References: |
Vias et al. 2023. Elife. 11 12:e83867. PMID: 37166279 Sevinyan et al. 2022. Cancers (Basel). 16 14(22):5628. PMID: 36428724 Asare-Werehene et al. 2023. Cancers (Basel). 30 15(9):2566. PMID: 37174032 |
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