OV-1946 cell line

Ascites-derived serous ovarian cancer cell line matched to solid-tumour-derived TOV-1946 from the same chemotherapy-naïve patient

Contributors

Inventor Institute
Anne-Marie Mes-Masson and Diane Provencher Centre Hospitalier de L’université de Montréal
SKU: 161771
Product description: OV-1946 was established from ascites from the same chemotherapy-naive patient from whom TOV-1946 was derived, providing a matched pair representing two disease compartments from a single patient. The two models carry the same somatic TP53 mutation while also displaying distinct chromosomal abnormalities. OV-1946 was shown to form spheroids and tumours in SCID mice, supporting its use alongside TOV-1946 to investigate which biological features are shared between solid-tumour- and ascites-derived disease and which differ by tumour compartment.
Alternate name: OV-1946
Gender: Female
CRISPR: No
Production details: Established from a mass of cells from ascites of patient 1946. Mass was macro-dissected and kept in 100mm petri dish for 27 days where they reached 80% confluence. Tissue was discarded and cells were divided 2:3 every week for the first 15 passages and 1:2 twice a week until passage 70. Cells were mantianed and divided 1:5 twice a week afterwards
Additional notes: Patient 1946 had no known familial history of cancer and passed from post-operative complications
Cellosaurus ID: CVCL_4375
Receptors of note: No
Related tools: 161770
Cat. #: 161771
Cancer types: Ovarian cancer
Research Fields: Cancer
Organism: Human
Tissue: Derived from matched ascites from case TOV-1946
Gender: Female
Morphology: Able to form less compact spheroids and expressed Krt7
Growth properties: Adherent
Primary citation: Ouellet et al. 2008. BMC Cancer. (8):152. PMID: 18507861
Shipping conditions: Dry Ice
Growth medium: OSE medium contains 10% FBS, 0.5ug/mL amphotericin B and 50 ug/mL gentamicin
Atmosphere: Hypoxic condition of 5%O2 and 5%CO2
References:

Sauriol et al. 2023. Sci Rep. 27

13(1):3334. PMID: 36849518 Sevinyan et al. 2022. Cancers (Basel). 16

14(22):5628. PMID: 36428724 Brodeur et al. 2021. Sci Rep. 14

11(1):18183. PMID: 34521878 Communal et al. 2021. Int J Mol Sci. 18

22(10):5325. PMID: 34070214 Patra et al. 2020 PLoS One. 31

15(12):e0244549. PMID: 33382759

Related Tools for Cell lines

Cat. # Tool Name
161770 TOV-1946 cell line Key Info View Tool

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