Dendritic Cell-Specific ICAM-3-Grabbing Non-Integrin (DC-SIGN; CD209) is a type II plasma membrane PRR abundantly expressed in antigen-presenting cells such as dendritic cells (DCs) and activated macrophages. As member of the C-type Lectin Receptor (CLR) family, DC-SIGN binds a plethora of pathogens, ranging from viruses like HIV-1, ebola virus, and hepatitis C virus, to larger pathogens like Mycobacterium tuberculosis and Candida albicans. This N80A mutant lacks the N-glycosylation ligand binding domain.
Alternate name:
DC-SIGN N8A
Conditional:
No
Production details:
CHO cell lines stably expressing DC-SIGN-N80 were established by Lipofectamin 2000 transfection, and were cultured in HamÄË?Â?Âs F-12 medium supplemented with 10% heat-inactivated FBS, 1% Antibiotic Antimycotic Solution , and 0.5ÄË?Â?Âmg/ml of the aminoglycoside antibiotic G418.
Parental cell line:
CHO
Disease:
HIV-1
Cat. #:
160717
Unit size:
1×10^6 cells / vial
Research Fields:
Cell signaling and signal transduction;Immunology
Organism:
Hamster
Tissue:
Ovary
Format:
Frozen
Shipping conditions:
Dry ice
Growth medium:
HamÄË?Â?Âs F-12 medium supplemented with 10% heat-inactivated FBS, 1% Antibiotic Antimycotic Solution , and 0.5ÄË?Â?Âmg/ml of the aminoglycoside antibiotic G418.
Human buccal mucosa modeling; Permeability, absorption and metabolism studies of various substances and enzymatically labile drugs; Drug delivery studies
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