NF-Î?B (nuclear factor kappaB) is a transcription factor that activates numerous target genes important in mediating innate and adaptive immunity in mammals. Activation by external stimuli such as TNF leads to the activation of kinases (IKK1 and IKK2) that phosphorylate inhibitory proteins I-Î?B and their subsequent degradation. IKK1 and IKK2 form the catalytic subunits of […]
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| A*STAR Accelerate Technologies Pte Ltd |
| Cat. #: | 152667 |
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| Unit size: | 100 ug |
| Research Fields: | Biochemistry;Genetics |
| Application: | IF ; WB |
| Target: | Splice variant of Zebrafish IKKg protein (154 amino acids) |
| Reactivity: | Human ; Zebrafish |
| Clone: | 1A5 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | NF-ÄÂ?B (nuclear factor kappaB) is a transcription factor that activates numerous target genes important in mediating innate and adaptive immunity in mammals. Activation by external stimuli such as TNF leads to the activation of kinases (IKK1 and IKK2) that phosphorylate inhibitory proteins I-ÄÂ?B and their subsequent degradation. IKK1 and IKK2 form the catalytic subunits of a complex which includes IKKÄÂ?, the regulatory component (also known as NEMO). Mutations in NEMO are the cause of the human disorders incontinentia pigmenti and ectodermal dysplasia (ED-AID). |
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| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | GST/His-tagged splice variant of Zebrafish IKK? protein of 154 amino acids fusion protein |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | NF-ÄÂ?B (nuclear factor kappaB) is a transcription factor that activates numerous target genes important in mediating innate and adaptive immunity in mammals. Activation by external stimuli such as TNF leads to the activation of kinases (IKK1 and IKK2) that phosphorylate inhibitory proteins I-ÄÂ?B and their subsequent degradation. IKK1 and IKK2 form the catalytic subunits of a complex which includes IKKÄÂ?, the regulatory component (also known as NEMO). Mutations in NEMO are the cause of the human disorders incontinentia pigmenti and ectodermal dysplasia (ED-AID). |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| Cat. # | Tool Name | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 151022 | Anti-IL12 [1-1A4] |
Key Info
Anti-IL12 [1-1A4]
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| 151027 | Anti-HSVICP8 [10A3] |
Key Info
Anti-HSVICP8 [10A3]
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| 151031 | Anti-RuvA [RuvA 12C6] |
Key Info
Anti-RuvA [RuvA 12C6]
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| 151040 | Anti-CD11 & CD18 [24] |
Key Info
Anti-CD11 & CD18 [24]
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| 151020 | Anti-CyclinB1 [V143.1] |
Key Info
Anti-CyclinB1 [V143.1]
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