Anti-SIGLEC1 [HSn 7D2]

Sialoadhesin is a macrophage-specific cell adhesion molecule that is expressed on activated macrophages in chronic inflammation and in tumours.

Contributors

Inventor Institute
Paul Crocker University of Dundee
SKU: 151199
Product description: The siglecs are a family of membrane bound lectins (of the immunoglobulin superfamily) that bind sialic acid and mediate cell-cell interactions. Family members include sialoadhesin, CD22 and CD33. Sialoadhesin is a macrophage-specific cell adhesion molecule that is expressed on activated macrophages in chronic inflammation and in tumours.
Alternate name: CD169, Sialoadhesin 1
Conjugation: Unconjugated
Isotype: IgG1
Immunogen: Fc fusion protein containing N-terminal 4 domains of human sialoadhesin.
Myeloma used: Sp2/0-Ag14
Cat. #: 151199
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Cell biology;Immunology
Application: ELISA ; FACS ; IHC ; RIA ; WB
Target: Sialoadhesin domains 1-4 (SIGLEC1)
Reactivity: Human
Clone: HSn 7D2
Host: Mouse
Class: Monoclonal
Target background: The siglecs are a family of membrane bound lectins (of the immunoglobulin superfamily) that bind sialic acid and mediate cell-cell interactions. Family members include sialoadhesin, CD22 and CD33. Sialoadhesin is a macrophage-specific cell adhesion molecule that is expressed on activated macrophages in chronic inflammation and in tumours.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Puryear et al. 2013. PLoS Pathog. 9(4):e1003291. PMID: 23593001.

Interferon-inducible mechanism of dendritic cell-mediated HIV-1 dissemination is dependent on Siglec-1/CD169.

Rempel et al. 2008. PLoS One. 3(4):e1967. PMID: 18414664.

Sialoadhesin expressed on IFN-induced monocytes binds HIV-1 and enhances infectivity.

Pack et al. 2008. Immunology. 123(3):438-46. PMID: 17944899.

DEC-205/CD205+ dendritic cells are abundant in the white pulp of the human spleen, including the border region between the red and white pulp.

Hartnell et al. 2001. Blood. 97(1):288-96. PMID: 11133773.

Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations.

Steiniger et al. 1997. Immunology. 92(2):307-16. PMID: 9415041.

The species-specific structure of microanatomical compartments in the human spleen: strongly sialoadhesin-positive macrophages occur in the perifollicular zone, but not in the marginal zone.

Images

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Adapted from Puryear et al. 2013. PLoS Pathog. 9(4)

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