Anti-RAET1E [RAET1E 79/6]

RAET1E (Retinoic Acid Early Transcript 1E), or ULBP4, is a member of the RAET1 family of major histocompatibility complex (MHC) class I-related genes.

Contributors

Institute
University of Cambridge
Cat. #: 151540
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Immunology
Application: ELISA ; FACS ; IF ; IP ; Fn ; WB
Target: RAET1E
Reactivity: Human
Clone: RAET1E 79/6
Host: Mouse
Class: Monoclonal
Alternate name: UL16 binding protein 4; NKG2D Ligand 4; Latel
Product description: RAET1E (Retinoic Acid Early Transcript 1E), or ULBP4, is a member of the RAET1 family of major histocompatibility complex (MHC) class I-related genes. RAET1E and RAET1G differ from the other RAET1 proteins by having a type I membrane-spanning sequence at their C termini rather than glycosylphosphatidylinositol anchor sequences. RAET1E is a functional ligand for NKG2D, which causes lymphocyte activation resulting in the secretion of cytokines.
Conjugation: Unconjugated
Isotype: IgG1 kappa
Immunogen: Recombinant protein of human RAET1E protein produced in E.coli with a N terminal 6x His tag
Target background: RAET1E (Retinoic Acid Early Transcript 1E), or ULBP4, is a member of the RAET1 family of major histocompatibility complex (MHC) class I-related genes. RAET1E and RAET1G differ from the other RAET1 proteins by having a type I membrane-spanning sequence at their C termini rather than glycosylphosphatidylinositol anchor sequences. RAET1E is a Fn ligand for NKG2D, which causes lymphocyte activation resulting in the secretion of cytokines.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

McGilvray et al. 2010. Int J Cancer. 127(6):1412-20. PMID: 20054857.

ULBP2 and RAET1E NKG2D ligands are independent predictors of poor prognosis in ovarian cancer patients.

Ohashi et al. 2010. J Biol Chem. 285(22):16408-15. PMID: 20304922.

Post-translational modification of the NKG2D ligand RAET1G leads to cell surface expression of a glycosylphosphatidylinositol-linked isoform.

Cao et al. 2007. J Biol Chem. 282(26):18922-8. PMID: 17470428.

RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity.

Eagle et al. 2006. Hum Immunol. 67(3):159-69. PMID: 16698438.

Regulation of NKG2D ligand gene expression.

Bacon et al. 2004. J Immunol. 173(2):1078-84. PMID: 15240696.

Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D.

Chalupny et al. 2003. Biochem Biophys Res Commun. 305(1):129-35. PMID: 12732206.

ULBP4 is a novel ligand for human NKG2D.

Radosavljevic et al. 2002. Genomics. 79(1):114-23. PMID: 11827464.

A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3.

Images

View Gallery
Adapted from Song M; Wang C; Wang H; Zhang T; Li J; Benezra R; Chouchane L; Sun YH; Cui XG; Ma X. Targeting ubiquitin protein ligase E3 component N-recognin 5 in cancer cells induces a CD8+ T cell mediated immune response. Oncoimmunology. 2020 Apr 14;9(1)

Related Tools for Antibodies

Cat. # Tool Name
151022 Anti-IL12 [1-1A4] Key Info View Tool
151027 Anti-HSVICP8 [10A3] Key Info View Tool
151029 Anti-HSVICP8 [11E2] Key Info View Tool
151017 Anti-MBP [R29.6] Key Info View Tool
151026 Anti-FCGR1 [10.1] mAb Key Info View Tool

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.