Anti-PAX9 monoclonal antibody [PAX9 7C2]

Contributors

Institute
Helmholtz Munich Core Facility Monoclonal Antibodies
SKU: 162375
Alternate name: Anti human/murine PAX9 monoclonal antibody (clone PAX9 7C2)
Conjugation: Unconjugated
Isotype: IgG1, k
Cat. #: 162375
Tool sub type: Primary antibody
Research Fields: Cell biology; Cell signaling and signal transduction; Developmental biology
Application: WB
Target: Human/murine PAX9
Reactivity: Human, mouse
Clone: PAX9 7C2
Host: Rat
Class: Monoclonal
Primary citation: Gerber et al. 2002. J. Pathol. 197: 293-297. PMID: 12115874
Target background: PAX9 has prognostic significance in esophageal squamous cell carcinoma (ESCC) and predicts radiation sensitivity. Progressive loss of PAX9 expression correlates with increasing malignancy of dysplastic and cancerous epithelium of the human oesophagus. PAX9 expression has been shown to mediate oncogene-induced cell survival in oral squamous cell carcinoma (Lee et al., 2008). On the other hand progressive loss of PAX9 expression correlates with increasing malignancy in esophageal cancers (Gerber et al., 2002)
References:

Gerber et al. 2002. J. Pathol. 197: 293-297. PMID: 12115874

Jonker et al. 2004. Mech. Dev. 121: 1313-1322. PMID: 15454262

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