Anti-Myelin Basic Protein (region 82-87) [MBP12]

MBP Clone 12 recognizes an epitope in the 82-87 region of MBP, useful in clinical diagnosis to detect MBP levels or myelination in human MBP.

Contributors

Institute
BioServ UK Ltd
Cat. #: 153641
Tool sub type: Primary antibody
Unit size: 100 ug
Cancer types: Brain cancer
Research Fields: Cell biology;Immunology;Neurobiology;Stem cell biology
Application: FACS ; ELISA ; IHC ; IF ; WB
Target: Myelin Basic Protein (region 82-87)
Reactivity: Chicken ; Human ; Guinea Pig ; Pig ; Rat ; Rabbit ; Sheep ; Mammals
Clone: MBP12
Host: Rat
Class: Monoclonal
Alternate name: Myelin basic protein, MBP, 2 kDa microtubule-stabilizing protein, Myelin A1 protein
Product description: Myelin Basic Protein (MBP) is involved in the process of myelination of nerves in the nervous system. MBP Clone 12 recognizes an epitope in the 82-87 region of MBP, useful in clinical diagnosis to detect MBP levels or myelination in human MBP. MBP 12 is also used in a two-site ELISA with clone MBP 40. Both are used interchangeably as capture and detection antibody.
Conjugation: Unconjugated
Isotype: IgG2a
Molecular weight: 13-21 kDa
Immunogen: Reacts with human MBP, recognizing epitopes in the 82-87 amino acid region (DENPVV)
Myeloma used: NS0
Target background: Myelin Basic Protein (MBP) is involved in the process of myelination of nerves in the nervous system. MBP Clone 12 recognizes an epitope in the 82-87 region of MBP, useful in clinical diagnosis to detect MBP levels or myelination in human MBP. MBP 12 is also used in a two-site ELISA with clone MBP 40. Both are used interchangeably as capture and detection antibody.
Format: Liquid
Shipping conditions: Dry ice
References:

Grigoletto et al. 2017. Acta Neuropathol Commun. 5(1):37. PMID: 28482862.

Higher levels of myelin phospholipids in brains of neuronal a-Synuclein transgenic mice precede myelin loss.

Friess et al. 2016. Cell Calcium. 60(5):322-330. PMID: 27417499.

Friess et al. 2016. Cell Calcium. 60(5):322-330. PMID: 27417499.

Fernandes et al. 2016. J Control Release. 238:300-310. PMID: 27369863.

Isoda et al. 2016. Neurosci Res. 110:18-28. PMID: 27083781.

Lim et al. 2016. Antioxidants (Basel). 5(…

Images

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Clone 12 used to detect MBP in myelinating cell cultures using Immunofluorescence. Time-lapse imaging of the putative assembly of myelin membrane. B) The cells from the Petri dish imaged with confocal microscopy were immunostained with anti-GFP and anti-MBP to confirm differentiation of cyto-GFP labelled oligodendrocytes. Source

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