Anti-Myelin Basic Protein [MBP40]

Monoclonal antibody used to detect MBP levels and myelination.

Contributors

Institute
BioServ UK Ltd
Cat. #: 153643
Tool sub type: Primary antibody
Unit size: 100 ug
Cancer types: Brain cancer
Research Fields: Cell biology;Immunology;Neurobiology;Stem cell biology
Application: ELISA
Target: Myelin Basic Protein
Reactivity: Chicken ; Human ; Guinea Pig ; Pig ; Rat ; Rabbit ; Sheep ; Mammals
Clone: MBP40
Host: Rat
Class: Monoclonal
Alternate name: Myelin basic protein, MBP, 2 kDa microtubule-stabilizing protein, Myelin A1 protein
Product description: Monoclonal antibody used to detect MBP levels and myelination. Background and Research Application Myelin Basic Protein (MBP) is involved in the process of myelination of nerves, oligodendrocytes and Schwann cells in the nervous system. MBP maintains the correct structure of myelin, interacting with the lipids in the myelin membrane. MBP clone 40 is used in clinical diagnostics to detect MBP levels or myelination in human MBP. MBP 40 is used in a two-site ELISA with clone MBP 12. Both are us…
Conjugation: Unconjugated
Isotype: IgG2a
Molecular weight: 13-21 kDa
Immunogen: Epitope unknown
Immunogen Uniprot ID: P02686
Myeloma used: NS0
Target background: Monoclonal antibody used to detect MBP levels and myelination. Background and Research Application Myelin Basic Protein (MBP) is involved in the process of myelination of nerves, oligodendrocytes and Schwann cells in the nervous system. MBP maintains the correct structure of myelin, interacting with the lipids in the myelin membrane. MBP clone 40 is used in clinical diagnostics to detect MBP levels or myelination in human MBP. MBP 40 is used in a two-site ELISA with clone MBP 12. Both are u…
Format: Liquid
Concentration: 1 mg/ml
Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
Shipping conditions: Dry ice
References:

Grigoletto et al. 2017. Acta Neuropathol Commun. 5(1):37. PMID: 28482862.

Higher levels of myelin phospholipids in brains of neuronal a-Synuclein transgenic mice precede myelin loss.

Friess et al. 2016. Cell Calcium. 60(5):322-330. PMID: 27417499.

Friess et al. 2016. Cell Calcium. 60(5):322-330. PMID: 27417499.

Fernandes et al. 2016. J Control Release. 238:300-310. PMID: 27369863.

Isoda et al. 2016. Neurosci Res. 110:18-28. PMID: 27083781.

Lim et al. 2016. Antioxidants (Basel). 5(…

Images

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Clone 12 used to detect MBP in myelinating cell cultures using Immunofluorescence. Time-lapse imaging of the putative assembly of myelin membrane. B) The cells from the Petri dish imaged with confocal microscopy were immunostained with anti-GFP and anti-MBP to confirm differentiation of cyto-GFP labelled oligodendrocytes. Source

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