Anti-Cytochrome P450 3A4 [F24 P2 B10]

Cytochrome P450 3A4 (CYP3A4) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP3A4 expressed mainly in the liver and intestine oxidizes xebiotics that are then removed from the body.

Contributors

Inventor Institute
Ayham Alnabulsi Vertebrate Antibodies Limited
Cat. #: 151862
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Cell signaling and signal transduction;Metabolism;Tissue-specific biology
Application: ELISA ; IHC ; WB
Target: CYP3A4 & CYP3A5 Cytochrome P450 3A4 (EC 1.14.13.67) (Quinine 3-monooxigenase)
Reactivity: Human
Clone: F24P2B10
Host: Mouse
Class: Monoclonal
Product description: Cytochrome P450 3A4 (CYP3A4) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP3A4 expressed mainly in the liver and intestine oxidizes xebiotics that are then removed from the body.
Conjugation: Unconjugated
Isotype: IgG1 kappa
Immunogen: Ovalbumin-conjugated synthetic peptide ESRDGTVSGA
Myeloma used: P3X63Ag8.653
Target background: Cytochrome P450 3A4 (CYP3A4) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP3A4 expressed mainly in the liver and intestine oxidizes xebiotics that are then removed from the body.
Format: Liquid
Concentration: 0.9-1.1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Murray et al. 2010. Histopathology. 57(2):202-11. PMID: 20716162.

Profiling the expression of cytochrome P450 in breast cancer.

Images

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Immunohistochemistry

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