The half life of CD74 on the cell surface is relatively short lasting only 3 to 4 min, before internalization. It has been suggested that CD74 on the cell surface binds MHC class II molecules which have lost their antigenic peptide promoting internalization and reloading with antigenic peptide.
| Inventor | Institute |
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| Margaret Goodall | University of Birmingham |
| SKU: | 153218 |
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| Product description: | CD74 is expressed primarily by antigen presenting cells such as B lymphocytes , macrophages and monocytes together, with many epithelialcells. CD74 may exist in different isoforms ranging in size from 33 to 41kDa, depending on genetic splicing. CD74 is a type II transmembrane protein which binds to the binding groove of nacent MHC class II alpha/beta heterodimers preventing their premature association with endogenous polypeptides. The half life of CD74 on the cell surface is relatively short … |
| Alternate name: | HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain; Cluster of Differentiation 74 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | B lymphoblastoid cell line: HFB1 |
| Cat. #: | 153218 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Bladder cancer |
| Research Fields: | Immunology |
| Application: | IHC |
| Target: | CD74 |
| Reactivity: | Human |
| Clone: | BU45 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | CD74 is expressed primarily by antigen presenting cells such as B lymphocytes , macrophages and monocytes together, with many epithelialcells. CD74 may exist in different isoforms ranging in size from 33 to 41kDa, depending on genetic splicing. CD74 is a type II transmembrane protein which binds to the binding groove of nacent MHC class II alpha/beta heterodimers preventing their premature association with endogenous polypeptides. The half life of CD74 on the cell surface is relatively short … |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Leucocyte Typing IV, (1989): edited by W. Knapp, OUP, Oxford. Leucocyte Typing V, (1995): edited by S.F. Schlossman, OUP, Oxford. Wraight et al. 1990. J Biol Chem. 265(10):5787-92. PMID: 1690714. Human major histocompatibility complex class II invariant chain is expressed on the cell surface. |
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