C11 may be used for differential diagnosis of lymphoma and carcinoma and identification of haemopoietic tumours.
| Inventor | Institute |
|---|---|
| Peter Beverley | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| SKU: | 151082 |
|---|---|
| Product description: | PTPRC, also known as CD45, is a transmembrane tyrosine phosphatase that is present on all leukocytes. It regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). C11 may be used for differential diagnosis of lymphoma and carcinoma and identification of haemopoietic tumours. |
| Alternate name: | Anti-PTPRC |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Molecular weight: | 180-222 kDa |
| Immunogen: | Human lymphocytes |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Cat. #: | 151082 |
|---|---|
| Provenance and Ownership: | The Anti-CD45 [C11] is owned by Cancer Research UK. CancerTools supplies the Anti-CD45 [C11] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-CD45 [C11] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology;Cell signaling and signal transduction;Immunology;Neurobiology;Stem cell biology;Tissue-specific biology |
| Application: | IHC ; IP |
| Target: | Protein tyrosine phosphatase, receptor type, C (PTPRC, CD45) |
| Reactivity: | Human |
| Clone: | C11 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | PTPRC is a transmembrane tyrosine phosphatase that is present on all leukocytes. PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). C11 may be used for differential diagnosis of lymphoma and carcinoma and identification of haemopoietic tumours. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Williams et al. 2003. Clin Exp Immunol. 131(1):68-74. PMID: 12519388. Dipeptidyl peptidase IV on activated T cells as a target molecule for therapy of rheumatoid arthritis. |
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