Anti-Bordotella avium 41-kDa Surface Protein [PF8]

Bordotella avium, a Gram-negative, aerobic and motile bacterium, is the causative agent of turkey coryza, an economically-impacting disease that can also infect other birds. The bacterium has been isolated from individuals with cystic fibrosis, although the contribution of the organism to the disease is still unclear.B. avium shares several virulence factors with human pathogens. A 41 kDa surface protein of B. avium is strongly associated with the organism’s virulence and ability to attach to tracheal mucosa. Monoclonal antibodies designated 9F8, 1G12 and 14G8 immunoprecipitate the 41kDa protein and also inhibited HA of guinea pig erythrocytes by B. avium. These antibodies…

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