An anti-anterior gradient 3 mouse monoclonal antibody
| Institute |
|---|
| Moravian Biotechnology |
| SKU: | 162064 |
|---|---|
| Product description: | Antibody created to detect the endogenous AGR3 protein (with weaker affinity than the Mouse anti- Anterior gradient 3 monoclonal antibody (AGR3.1]). Binding specificity: human AGR3 protein. Epitope QYSQALKKV (determined using pepscan) |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Molecular weight: | Calculated: 19,6 kDa; SDS-PAGE mobility (reduced): 19-20 kDa. |
| Immunogen: | Purified human AGR3 protein |
| Cat. #: | 162064 |
|---|---|
| Tool sub type: | Primary antibody |
| Target: | Anterior gradient 3 |
| Reactivity: | Human |
| Clone: | AGR3.2 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | AGR3 (Anterior Gradient 3) is a human homologue of the XAG-2 protein expressed in Xenopus laevis, which was identified in a study analyzing mRNA expression in ER-positive breast cancer-derived cell lines. The coding sequence of the AGR3 protein is located on the chromosome at position 7p21. AGR3 expression in ovarian cancer is independent of oestrogen-receptor expression, which is distinct from the oestrogen-receptor dependent expression of AGR3 in breast cancers. Isogenic cancer cell models were created that over-express AGR3 and these demonstrated that AGR3 mediates cisplatin-resistance in mouse xenografts. These data indicate that AGR3 is over-expressed by a hormone (oestrogen-receptor ?)-independent mechanism and identify a novel protein-folding associated pathway that could mediate resistance to DNA-damaging agents in human cancers. |
|---|
| Format: | Liquid |
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| Shipping conditions: | Dry ice |
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