Cat. #158322
NBQ-48 small molecule
Cat. #: 158322
Sub-type: Inhibitor
Availability: Please enquire for quantities and pricing
Application: cell hypoxia marker; fluorescence-based multiplex ELISA
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Osvaldo Cox (Retired), Beatriz Zayas
Institute: Universidad Ana G. Mendez
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: NBQ-48 small molecule
- Research fields: Cancer;Cell biology
- Molecular formula: C22H26CIN3O2
- Tool sub type: Inhibitor
- Description: Inhibitor of growth in several cancer cell line models. This small molecule can also be used as a cell hypoxia marker in 2D and 3D colon cancer cell models.
- Application: cell hypoxia marker; fluorescence-based multiplex ELISA
- Iupac: 7-benzyl-3- nitrobenzimidazo[3,2-a]quinolinium chloride
- Molecular weight: 389.8348
- Solubility: 3 mM in water, 10ľM DMSO; 100 ľg/mL in DMSO
Handling
- Purity: 389.8348 g/mol
- Storage conditions: 2-5° C in solution
- Shipping conditions: Dry Ice
Target Details
- Ic50: 100 uM (COLO205 cells under hypoxic conditions); 128 uM +/- 3 uM (U937 cells)
Application Details
- Application: cell hypoxia marker; fluorescence-based multiplex ELISA
References
- VĂŠlez et al. 2017. Open Med Chem J. 11:54-65. PMID: 28761559.
- Otero et al. 2015. J Cancer Res Ther Oncol. 1:. PMID: 26086027.
- Vivas-MejĂa et al. 1998. Mol Cell Biochem. 178(1-2):203-12. PMID: 9546601.
