Selective CB2R photoaffinity probe (LEI-121) small molecule (tool compound)

CB2R-selective bifunctional probe that covalently captures CB2R upon photoactivation. LEI121 enables target engagement studies and visualization of endogenously expressed CB2R.

Contributors

Institute
Leiden University and Leiden University Medical Center
SKU: 156467
Product description: Photoreactive probe to study the type 2 cannabinoid receptor (CB2R). LEI121 is the first CB2R-selective bifunctional probe that covalently captures CB2R upon photoactivation. An incorproated alkyne serves as ligation handle for the introduction of reporter groups.
Additional notes: Using proteomics, LEI-121 has shown to identify multidrug resistance protein 1, protein disulfide-isomerase, glutathione S-transferase Mu 6, 26S proteasome non-ATPase regulatory subunit 3 O and mitochondrial carnitine.acylcarnitine carrier protein.
Molecular weight: 657
Cat. #: 156467
Tool sub type: Fluorescent Probe
Research Fields: Drug development; Cell biology
Application: Enables target engagement studies and visualisation of endogenously expressed CB2R.
References:

Soethoudt et al. 2018. Cannabis Cannabinoid Res. 3(1):136-151. PMID: 29992186.

Soethoudt et al. 2018. J Am Chem Soc. 140(19):6067-6075. PMID: 29420021.

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