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#157972

LOX Inhibitor CCT365623 Small Molecule (Tool Compound)

Cat. #157972

LOX Inhibitor CCT365623 Small Molecule (Tool Compound)

Cat. #: 157972

Sub-type: Inhibitor

Availability: Please enquire for quantities and pricing

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Contributor

Inventor: Leo Leung ; Caroline Springer

Institute: Cancer Research UK, Manchester Institute

Tool Details
Handling
Target Details
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Tool name: LOX Inhibitor CCT365623 Small Molecule (Tool Compound)
  • Alternate name: LOX, protein-6-lysine oxidase
  • Research fields: Cell biology;Developmental biology
  • Tool sub type: Inhibitor
  • Primary target: Lysyl oxidase
  • Description: Lysyl oxidase (LOX) and its family members LOX-like (LOXL) are copper-dependent amine oxidases that covalently cross-link collagens and elastin in the tumor extracellular matrix. LOX is secreted as a catalytically inactive 50 kDa pro-protein, which is cleaved to an active 32 kDa enzyme by proteases such as procollagen C-proteinase. LOX and LOXL have variable N-termini, and share a highly conserved C-terminus, where the catalytic domain is located. The catalytic site comprises a copper binding...
  • Purpose: Inhibitor
  • Additional notes: Patent Application Number WO 2017/141049 A1

Handling

  • Shipping conditions: Dry Ice

Target Details

  • Primary target: Lysyl oxidase
  • Ic50: 0.90ÎźM

References

  • Leung et al. 2019. J Med Chem. 62(12):5863-5884. PMID: 31070916.

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