LOX Inhibitor CCT365623 Small Molecule (Tool Compound)

An inhibitor of LOX. LOX and LOXL2 have important roles in promoting tumor growth in many types of cancer and LOX has been demonstrated to be a critical mediator of cancer metastasis

Contributors

Inventor Institute
Leo Leung ; Caroline Springer Cancer Research UK, Manchester Institute
Cat. #: 157972
Tool sub type: Inhibitor
Research Fields: Cell biology;Developmental biology
Purpose: Inhibitor
Alternate name: LOX, protein-6-lysine oxidase
Product description: Lysyl oxidase (LOX) and its family members LOX-like (LOXL) are copper-dependent amine oxidases that covalently cross-link collagens and elastin in the tumor extracellular matrix. LOX is secreted as a catalytically inactive 50 kDa pro-protein, which is cleaved to an active 32 kDa enzyme by proteases such as procollagen C-proteinase. LOX and LOXL have variable N-termini, and share a highly conserved C-terminus, where the catalytic domain is located. The catalytic site comprises a copper binding…
Additional notes: Patent Application Number WO 2017/141049 A1
Primary target: Lysyl oxidase
Shipping conditions: Dry Ice
References:

Leung et al. 2019. J Med Chem. 62(12):5863-5884. PMID: 31070916.

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