Heat shock protein 70 (HSP70) inhibitor JG-345

JG-345 was designed as a small molecule with greater stability and potency to inhibit members of the heat shock protein 70 (Hsp70) family of molecular chaperones.

Contributors

Inventor Institute
Jason Gestwicki University of Michigan
Cat. #: 157978
Tool sub type: Inhibitor
Research Fields: Cancer
Purpose: Inhibitor
Product description: The benzothiazole rhodacyanines, MKT-077 analogue, JG-345 was designed as a small molecule with greater stability and potency to inhibit members of the heat shock protein 70 (Hsp70) family of molecular chaperones. Inhibiting Hsp70 chaperones induce apoptosis in breast cancer cell lines. This inhibitor would be useful in the study of Hsp70 chaperones and oncology research.
Primary target: Heat shock protein 70 (HSP70)
Shipping conditions: Dry Ice
References:

Shao et al. 2020. Bioorg Med Chem Lett. 30(5):126954. PMID: 31952963.

Taguwa et al. 2019. Cell Rep. 26(4):906-920.e3. PMID: 30673613.

Rinaldi et al. 2018. ACS Chem Biol. 13(11):3142-3152. PMID: 30372610.

Shao et al. 2018. J Med Chem. 61(14):6163-6177. PMID: 29953808.

Young et al. 2016. Cell Chem Biol. 23(8):992-1001. PMID: 27499529.

Li et al. 2013. ACS Med Chem Lett. 4(11):. PMID: 24312699.

Rousaki et al. 2011. J Mol Biol. 411(3):614-32. PMID: 21708173.

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