#157978

Heat shock protein 70 (HSP70) inhibitor JG-345

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Cat. #157978

Heat shock protein 70 (HSP70) inhibitor JG-345

Cat. #: 157978

Sub-type: Inhibitor

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This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Jason Gestwicki

Institute: University of Michigan

Tool Details
Handling
Target Details
Related Tools
References

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: Heat shock protein 70 (HSP70) inhibitor JG-345
  • Research fields: Cancer
  • Tool sub type: Inhibitor
  • Primary target: Heat shock protein 70 (HSP70)
  • Description: The benzothiazole rhodacyanines, MKT-077 analogue, JG-345 was designed as a small molecule with greater stability and potency to inhibit members of the heat shock protein 70 (Hsp70) family of molecular chaperones. Inhibiting Hsp70 chaperones induce apoptosis in breast cancer cell lines. This inhibitor would be useful in the study of Hsp70 chaperones and oncology research.
  • Purpose: Inhibitor

Handling

  • Shipping conditions: Dry Ice

Target Details

  • Primary target: Heat shock protein 70 (HSP70)

Related Tools

  • Related tools: Heat shock protein 70 (HSP70) inhibitor JG-231 ; Heat shock protein 70 (HSP70) inhibitor JG-98

References

  • Shao et al. 2020. Bioorg Med Chem Lett. 30(5):126954. PMID: 31952963.
  • Taguwa et al. 2019. Cell Rep. 26(4):906-920.e3. PMID: 30673613.
  • Rinaldi et al. 2018. ACS Chem Biol. 13(11):3142-3152. PMID: 30372610.
  • Shao et al. 2018. J Med Chem. 61(14):6163-6177. PMID: 29953808.
  • Young et al. 2016. Cell Chem Biol. 23(8):992-1001. PMID: 27499529.
  • Li et al. 2013. ACS Med Chem Lett. 4(11):. PMID: 24312699.
  • Rousaki et al. 2011. J Mol Biol. 411(3):614-32. PMID: 21708173.