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#161689

EHop-016 Rac1 Inhibitor

Cat. #161689

EHop-016 Rac1 Inhibitor

Cat. #: 161689

Availability: 3-4 weeks

Application: Further development as a pharacological inhibitor of Rac activity in metastatic cancer cells

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Suranganie Dharmawardhane

Institute: University of Puerto Rico

Primary Citation: Montalvo-Ortiz et al. J Biol Chem. 287(16): 13228-13238. PMID: 22383527

Tool Details
Target Details
Application Details
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Tool name: EHop-016 Rac1 Inhibitor
  • Cancer: Breast cancer
  • Research fields: Cancer
  • Primary target: Rac
  • Secondary targets: Rac 1 and Rac 3
  • Description: EHop-016 Rac1 Inhibitor is a novel small molecule directed at metastatic breast cancer. Potent Rac inhibitor reporting the identification and characterization of the biological activity of EHop-016, a novel NSC23766 derivative that inhibits Rac1 100-fold more effectively than the parent compound.
  • Application: Further development as a pharacological inhibitor of Rac activity in metastatic cancer cells
  • Purpose: Designed to be a more potent Rac Inhibitor with possible clinical applications

Target Details

  • Primary target: Rac
  • Secondary targets: Rac 1 and Rac 3
  • Ic50: 1.1mu.M

Application Details

  • Application: Further development as a pharacological inhibitor of Rac activity in metastatic cancer cells

References

  • Montalvo-Ortiz et al. J Biol Chem. 287(16): 13228-13238. PMID: 22383527

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