Cat. #161689
EHop-016 Rac1 Inhibitor
Cat. #: 161689
Application: Further development as a pharacological inhibitor of Rac activity in metastatic cancer cells
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Contributor
Inventor: Suranganie Dharmawardhane
Institute: University of Puerto Rico
Primary Citation: Montalvo-Ortiz et al. J Biol Chem. 287(16): 13228-13238. PMID: 22383527
Tool Details
*FOR RESEARCH USE ONLY
- Tool name: EHop-016 Rac1 Inhibitor
- Primary target: Rac
- Secondary targets: Rac 1 and Rac 3
- Description: EHop-016 Rac1 Inhibitor is a novel small molecule directed at metastatic breast cancer. Potent Rac inhibitor reporting the identification and characterization of the biological activity of EHop-016, a novel NSC23766 derivative that inhibits Rac1 100-fold more effectively than the parent compound.
- Application: Further development as a pharacological inhibitor of Rac activity in metastatic cancer cells
- Purpose: Designed to be a more potent Rac Inhibitor with possible clinical applications
Target Details
- Primary target: Rac
- Secondary targets: Rac 1 and Rac 3
- Ic50: 1.1mu.M
Application Details
- Application: Further development as a pharacological inhibitor of Rac activity in metastatic cancer cells
References
- Montalvo-Ortiz et al. J Biol Chem. 287(16): 13228-13238. PMID: 22383527
