anti-carbonic anhydrase IX (CA-IX) iBody small molecule (tool compound)

An enzyme that in humans is encoded by the CA9 gene

Contributors

Inventor Institute
Jan Konvalinka ; Jirí Schimer ; Tomas Knedlik ; Jan Tykvart ; Frantisek Sedlak ; Pavel Majer ; Vaclav Navratil ; Petr Cigler ; Vladimir Subr ; Karel Ulbich ; Jiri Stroham ; Pavel Sacha Institute of Organic Chemistry and Biochemistry ; Institute of Macromolecular Chemistry ; Charles University
Cat. #: 157993
Tool sub type: Marker
Research Fields: Cell signaling and signal transduction;Other
Purpose: Marker
Alternate name: Carbonic Anyhdrase IX; CA9; CA-IX
Product description: An enzyme that in humans is encoded by the CA9 gene. – iBodiesŽ are capable of replacing antibodies in biomedical applications such as ELISA, flow cytometry, confocal microscopy, immunocytochemistry, Western Blot and immunoprecipitation. – These iBodiesŽ consist of an N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer decorated with low-molecular-weight compounds that function as targeting ligand (e.g., enzyme inhibitors, receptor ligands), affinity anchor (e.g., biotin) and/or imaging prob…
Additional notes: HPMA conjugate characteristics: MW: 111 000g/mol #Biotins/molecule: 33 Fluorochrome name: ATTO488 #Fluorochrome/molecule: 6 iBodies(R) is a registered trade mark of IOCB Tech s.r.o.
Primary target: Targeting human Carbonic Anhydrase (CAIX) using CAIX specific inhibitor
Shipping conditions: Dry Ice
References:

Ĺ imon et al. 2018. ACS Chem Biol. 13(12):3333-3342. PMID: 30489064.

Dvořáková et al. 2017. J Med Chem. 60(20):8385-8393. PMID: 28953383.

Ĺ ĂĄcha et al. 2016. Angew Chem Int Ed Engl. 55(7):2356-60. PMID: 26749427.

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