4-trifluoromethyl-7-hydrazinyl-2H-chromen-2-one (TFCH) biomolecular fluorophore small molecule (tool compound)

Detection of Oxidative Stress damage in a myriad of cells and tissues.Detection of an early biomarker for disease, toxicity, cell and tissue damage.Use in live cells and tissues, fixed cells and tissues and existing biopsy material.

Contributors

Inventor Institute
Susan Bane ; Kamalika Mukherjee Binghamton University
Cat. #: 160832
Tool sub type: Fluorescent Probe
Research Fields: Drug development;Cell biology
Application: Renal tissue imaging. Live cell screening
Alternate name: TFCH
Product description: 4-trifluoromethyl-7-hydrazinyl-2H-chromen-2-one (TFCH) is a novel fluorescent biocompatible probe has been developed to detect oxidative damage in live cells and tissues in as little as 5 minutes. TO accomplish this, TFCH utilizes the irreversible reaction of radicals with biomolecules that result in the covalent addition of carbonyls to biomolecules. This probe has been shown to outperform other commercially available toxicity and reactive oxygen species assays. This probe has been shown to …
References:

A Highly Sensitive Fluorogenic Assay for the Detection of Nephrotoxin-Induced Oxidative Stress in Live Cells and Renal Tissue

Mukherjee et al. 2021. ACS Sens. 6(7):2523-2528. PMID: 34214393.

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