MGMT inhibitor Lomeguatrib Small Molecule (Tool Compound)
Cat. #:
151711
Sub-type:
Inhibitor
Availability:
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Application:
Lomeguatrib (20 mg/kg/day for 5 days) combined with Temozolomide (100 mg/kg/day for 5 days) produces a substantial tumour growth delay: median tumour quintupling time is increased by 22 days without any significant increase in toxicity, while neither of the two drugs administrated along show any antitumor activity. Lomeguatrib inactivates ATase and enhances the anti-tumour effect of Temozolomide in A375M human melanoma xenografts model. Lomeguatrib, at a single dose of 20 mg/kg i.p., produces…
Antitumoral Quinol1h Small Molecule (Tool Compound)
Cat. #:
151834
Sub-type:
Antitumoral
Availability:
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Application:
Antitumor activity observed in HCT 116 (GI50 = 40 nM) and HT 29 (GI50 = 380 nM), and in breast cancer cell lines. Potent inhibitory effect in NCI 60 cells (GI50 =16 nM and LC50 = 2.24 ÂľM).
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