PL5 Peptide

This bi-specific peptide has enhanced affinity to bind to receptor proteins so PL5 may be useful as an affinity ligand for delivery of diagnostic compound into solid tumours.

Contributors

Inventor Institute
Prakash Lingasamy ; Tambet Teesalu University of Tartu
Cat. #: 157664
Tool sub type: Synthetic Peptide
Research Fields: Cancer;Cell biology
Alternate name: PL5, Bi-specific tenascin-C and fibronectin targeted peptide
Product description: Oncofetal fibronectin (FN-EDB) and tenascin-C C domain (TNC-C) are not present in the extracellular matrix of adult tissues but they are up-regulated in tumours and malignant tissues. Both have been used as targets for antibody-based therapies. This bi-specific peptide has enhanced affinity to bind to these receptor proteins so PL5 may be useful as an affinity ligand for delivery of diagnostic compound into solid tumours.
Function: Marker
Expression system: Synthetic
References:

Lingasamy et al. 2019. Biomaterials. 219:119373. PMID: 31374479.

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