#157783

Sox10iCre/+; Myrffl/fl mouse

Cat. #157783

Sox10iCre/+; Myrffl/fl mouse

Cat. #: 157783

Sub-type: Mouse

Availability: 6-8 weeks

Disease: Tamoxifen activated inactivation of Myrf for demyelination of throughout the CNS

Model: Conditional KO

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Contributor

Inventor: Ben Emery

Institute: Oregon Health & Science University

Tool Details
Handling
Target Details
References

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: Sox10iCre/+; Myrffl/fl mouse
  • Research fields: Neurobiology
  • Tool sub type: Mouse
  • Disease: Tamoxifen activated inactivation of Myrf for demyelination of throughout the CNS
  • Model: Conditional KO
  • Conditional: Yes
  • Conditional description: inducible demyelination without remyelination
  • Description: Deymelination restricted to CNS & lack of remyelination.
  • Genetic background: MyrfFl/Fl mouse line crossed with a Sox10-CreERT transgenic line expressing tomoxifen inducible Cre recombinase in the oligodendrocyte lineage.
  • Phenotype: Demyelination of CNS
  • Strain: C57BL/6
  • Breeding information: Sox10iCre/+;MyrfFl/Fl mouse line can be bred with Sox10+/+;MyrfFl/Fl mice where 50% offspring will be Sox10iCre/+.

Handling

  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Target Details

  • Target: Myrf (myelin regulatory factor)

References

  • 30996143 19596243
  • McKenzie et al. 2014. Science. 346(6207):318-22. PMID: 25324381.
  • Koenning et al. 2012. J Neurosci. 32(36):12528-42. PMID: 22956843.