TO14 Cell Line

TO14 is an adherent cell line derived from a metastasis to the omentum from a patient with a well differentiated serous adenocarcinoma

Contributors

Inventor Institute
Simon Langdon Cancer Research UK Edinburgh Centre
Cat. #: 151680
Tool sub type: 10XUAS IVS p10
Unit size: 1×10^6 cells / vial
Organism: Human
Tissue: Ovary
Gender: Male
Growth properties: Adherent
Alternate name: T014
Product description: TO14 is an adherent cell line derived from a metastasis to the omentum obtained at hysterectomy from a patient with a well differentiated serous adenocarcinoma. TO14 is from the same patient as PEO14 and PEO23 cell lines. This is a oestrogen receptor negative cell line.  TO14 cell line morphology: epithelial; stellate in shape and producing hemicystic colonies which grow upwards from the substrate and detach as spheres. The TO14 cell line is 1 of 9 from the PE ovarian adenocarcinoma panel (derived from 4 patients at varying stages of ovarian cancer, isolated from various malignant sites, and at various treatment stages). These cell lines provide a model system for research into the mechanism of oestrogen action on ovarian adenocarcinoma tumour cells, and for the study of efficacy and toxicity of oestrogen protagonists.
Gender: Male
CRISPR: Yes
Conditional: Yes
Cellosaurus ID: CVCL_2734
Format: Frozen
Shipping conditions: Dry ice
Growth medium: RPMI 1640 + 2mM Glutamine + 2mM Sodium Pyruvate + 10% Foetal Bovine Serum (FBS).
Mycoplasma free: Yes
References:

Langdon et al. 1990. Br J Cancer. 62(2):213-6. PMID: 2386737.

Oestrogen receptor expression and the effects of oestrogen and tamoxifen on the growth of human ovarian carcinoma cell lines.

Langdon et al. 1988. Cancer Res. 48(21):6161-5. PMID: 3167862.

Langdon et al. 1988. Cancer Res. 48(21):6166-72. PMID: 3167863.

Effect of sodium butyrate and other differentiation inducers on poorly differentiated human ovarian adenocarcinoma cell lines.

Characterization and properties of nine human…

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TO14 Cell Line. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC).

Citations And Reviews

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