PEO14 Cell Line

…a patient with a well differentiated serous adenocarcinoma. PEO14 was collected prior to treatment. PEO14 exhibits poor growth in semi-solid medium (agar). PEO14 is from the same patient as PEO16…

Contributors

Inventor Institute
Simon Langdon Cancer Research UK Edinburgh Centre
SKU: 151675
Product description: PEO14 is a patient-derived human serous ovarian cancer cell line established from malignant ascites and included in the PE ovarian adenocarcinoma panel. It forms a patient-matched pair with PEO23, which was derived from the same patient at a later, platinum-resistant relapse stage. PEO14 can be used as the earlier comparator in studies of drug response, resistance-associated change and inter-model heterogeneity, while complementing the broader PEO-prefixed ovarian cancer models available from CancerTools.
Gender: Female
Conditional: Yes
Additional notes: PEO14 is one of nine cell lines from the PE ovarian adenocarcinoma panel, which was derived from four patients at different stages of ovarian cancer, from various malignant sites and at various treatment stages. The wider panel has been used as a model system for research into mechanisms of oestrogen action in ovarian adenocarcinoma tumour cells and for studies of oestrogen agonist/antagonist efficacy and toxicity. PEO14 was collected prior to treatment and has been reported to show poor growth in semi-solid medium, including agar.
Cellosaurus ID: CVCL_2687
Disease: Cancer
Cat. #: 151675
Provenance and Ownership: The PEO14 Cell Line is owned by Cancer Research UK. CancerTools supplies the PEO14 Cell Line under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing PEO14 Cell Line directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Unit size: 1×10^6 cells / vial
Cancer types: Ovarian cancer
Research Fields: Cancer;Drug development
Organism: Human
Tissue: Ovary
Gender: Female
Model: Tumour line
Growth properties: Adherent
Cancer Types In Detail: Adenocarcinoma
Format: Frozen
Shipping conditions: Dry ice
Growth medium: RPMI-1640 + 2mM Glutamine + 2mM Sodium Pyruvate + 10% Foetal Bovine Serum.
Subculture routine: Split sub-confluent cultures (70-80%) 1:4 to 1:10 seeding at 2- 3 x 10^4 cells/cm² using 0.05% trypsin or trypsin/EDTA; 5% CO₂; 37°C. Doubling time approximately 108 hours.
References:

Langdon et al. 1990. Br J Cancer. 62(2):213-6. PMID: 2386737.

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PEO14 Cell Line. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC)

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