PEA2 Cell Line

PEA2 cell line: One of nine from the PE ovarian adenocarcinoma panel. Adherent cell collected on relapse after treatment with cisplatin and prednimustine.

Contributors

Inventor Institute
Simon Langdon Cancer Research UK Edinburgh Centre
Cat. #: 151679
Tool sub type: 10XUAS IVS p10
Unit size: 1×10^6 cells / vial
Cancer types: Ovarian cancer
Organism: Human
Tissue: Ovary
Gender: Male
Model: Tumour line
Growth properties: Adherent
Cancer Types In Detail: Adenocarcinoma;Adenocarcinoma
Product description: The PEA2 cell line is one of nine from the PE ovarian adenocarcinoma panel (derived from 4 patients at varying stages of ovarian cancer, isolated from various malignant sites, and at various treatment stages) which provides a model system for research into the mechanism of oestrogen action on ovarian adenocarcinoma tumour cells, and for the study of efficacy and toxicity of oestrogen protagonists. PEA2 is an adherent cell line derived from a malignant effusion from the peritoneal ascites of a patient with a poorly differentiated adenocarcinoma. PEA2 was collected on relapse after treatment with cisplatin and prednimustine and exhibits poor growth in semi-solid medium (agar). It is from the same patient as the PEA1 cell line.
Gender: Male
CRISPR: Yes
Conditional: Yes
Cellosaurus ID: CVCL_2683
Disease: Cancer;Cancer
Format: Frozen
Shipping conditions: Dry ice
Growth medium: RPMI 1640 + 2mM Glutamine + 2mM Sodium Pyruvate + 10% Foetal Bovine Serum (FBS).
Subculture routine: Split sub-confluent cultures (70-80%) 1:4 to 1:10 seeding at 2- 3 x 10^4 cells/cm² using 0.05% trypsin or trypsin/EDTA; 5% CO₂; 37°C. Doubling time is approximately 66 hours.
Mycoplasma free: Yes
References:

Matassa et al. 2016. Cell Death Differ. :. PMID: 27206315.

Beaufort et al. 2014. PLoS One. 9(9):e103988. PMID: 25230021.

Langdon et al. 1990. Br J Cancer. 62(2):213-6. PMID: 2386737.

Langdon et al. 1988. Cancer Res. 48(21):6166-72. PMID: 3167863.

Images

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PEA2 Cell Line. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC)

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