CovCis Cell Line

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Cisplatin-resistant COV318-derived HGSC cell line for comparing platinum resistance across tumour backgrounds

Contributors

Inventor Institute
Michelle Lockley Queen Mary University of London, UK.
SKU: 161762
Product description: CovCis is a cisplatin-resistant derivative of COV318 generated by serial culture under increasing cisplatin exposure. Used alongside OV4Cis and OvsahoCis, it provides an additional parental background for testing whether adaptations observed following cisplatin selection recur across different HGSC models or remain model-specific. The wider resistant panel showed recurrent gene-expression changes that overlap with samples from patients with relapsed HGSC, providing a clinically relevant framework for comparative studies of platinum resistance
Gender: Female
CRISPR: No
Production details: Cells were cultured in vitro in increasing concentrations of either cisplatin or carboplatin until an increase in IC50 between two and ten-fold was achieved to reflect the resistance observed in human patients
Cellosaurus ID: CVCL_E5FS
Parental cell line: Cov318 cell line
Model description: Platinum-resistant HGSC in vivo cell line
Related tools: 161760 ; 161761 ; 161763 ; 161759 ; 161758
Cat. #: 161762
Provenance and Ownership: The CovCis Cell Line is owned by Cancer Research UK. CancerTools supplies the CovCis Cell Line under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing CovCis Cell Line directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Cancer types: Ovarian cancer
Research Fields: Cancer
Organism: Human
Tissue: Ovary
Gender: Female
Model: Mutant
Growth properties: Adherent
Primary citation: J I Hoare et al. 2022. Gynecol Oncol. 167(1):96-106. PMID: 35918200.
Growth medium: DMEM containing 10% FBS and 1% penicillin/streptomycin. Cells should be cultured without drug but used at low passage to ensure drug resistance is maintained.
Temperature: 37° C
Mycoplasma free: Yes
References:

J I Hoare et al. 2022. Gynecol Oncol. 167(1):96-106. PMID: 35918200.

Images

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Platinum-resistance can be induced in HGSC cell lines and is maintained after drug withdrawal.

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