IVRO1 Cell Line

Platinum-resistant HGSC cancer cells.

Contributors

Inventor Institute
Michelle Lockley Queen Mary University of London, UK.
SKU: 161758
Product description: Platinum-resistant HGSC cancer cells.
Gender: Female
CRISPR: No
Production details: Mice with OVCAR4 intraperitoneal xenografts initially responded to carboplatin but tumours eventually regrew indicating the in vivo development of carboplatin-resistance. Murine tumours were harvested at necropsy and dissociated to create IVR01.
Parental cell line: OVCAR4-Luc cell lines
Model description: Platinum-resistant HGSC in vivo cell line
Cat. #: 161758
Cancer types: Ovarian cancer
Research Fields: Cancer
Organism: Human
Tissue: Ovary
Gender: Female
Model: Mutant
Growth properties: Adherent
Primary citation: J I Hoare et al. 2022. Gynecol Oncol. 167(1):96-106. PMID: 35918200.
Initial handling information: Cells should be cultured without drug but used at low passage to ensure drug resistance is maintained
Growth medium: DMEM containing 10% FBS and 1% penicillin/streptomycin. Cells should be cultured without drug but used at low passage to ensure drug resistance is maintained.
Temperature: 37° C
Mycoplasma free: Yes
References:

J I Hoare et al. 2022. Gynecol Oncol. 167(1):96-106. PMID: 35918200.

Images

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IVR01 (purple) and IVR02 (pink). The IP OVCAR4-Luc tumours of two carboplatin-treated mice were harvested at end point

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