Mice with OVCAR4 intraperitoneal xenografts initially responded to carboplatin but tumours eventually regrew indicating the in vivo development of carboplatin-resistance. Murine tumours were harvested at necropsy and dissociated to create IVR01.
Parental cell line:
OVCAR4-Luc cell lines
Model description:
Platinum-resistant HGSC in vivo cell line
Cat. #:
161758
Cancer types:
Ovarian cancer
Research Fields:
Cancer
Organism:
Human
Tissue:
Ovary
Gender:
Female
Model:
Mutant
Growth properties:
Adherent
Primary citation:
J I Hoare et al. 2022. Gynecol Oncol. 167(1):96-106. PMID: 35918200.
Initial handling information:
Cells should be cultured without drug but used at low passage to ensure drug resistance is maintained
Growth medium:
DMEM containing 10% FBS and 1% penicillin/streptomycin. Cells should be cultured without drug but used at low passage to ensure drug resistance is maintained.
Temperature:
37° C
Mycoplasma free:
Yes
References:
J I Hoare et al. 2022. Gynecol Oncol. 167(1):96-106. PMID: 35918200.
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