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#151521

Anti-XPF [XPF 3F2/3]

Cat. #151521

Anti-XPF [XPF 3F2/3]

Cat. #: 151521

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 3-4 weeks

Target: XPF

Class: Monoclonal

Application: ELISA ; IHC ; IF ; WB

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Anti-XPF [XPF 3F2/3]
  • Research fields: Genetics
  • Clone: XPF 3F2/3
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Strain: Balb/c
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; IHC ; IF ; WB
  • Description: Nucleotide excision repair (NER) is a DNA repair pathway that removes lesions induced by a variety of agents such as UV irradiation. ERCC1 and XPF form the heterodimer ERCC1-XPF, forming a DNA endonuclease that is essential for the dual incision step of NER (cleaves 5' of the DNA lesion).
  • Immunogen: A recombinant His-tagged fragment of human XPF protein produced in E. coli
  • Isotype: IgG1
  • Myeloma used: Sp2/0-Ag14

Target Details

  • Target: XPF
  • Target background: Nucleotide excision repair (NER) is a DNA repair pathway that removes lesions induced by a variety of agents such as UV irradiation. ERCC1 and XPF form the heterodimer ERCC1-XPF, forming a DNA endonuclease that is essential for the dual incision step of NER (cleaves 5' of the DNA lesion).

Applications

  • Application: ELISA ; IHC ; IF ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Dry ice

References

  • Facista et al. 2012. Genome Integr. 3(1):3. PMID: 22494821.
  • Deficient expression of DNA repair enzymes in early progression to sporadic colon cancer.
  • Bhagwat et al. 2009. Cancer Res. 69(17):6831-8. PMID: 19723666.
  • Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue.

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