Cat. #151521
Anti-XPF [XPF 3F2/3]
Cat. #: 151521
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: XPF
Class: Monoclonal
Application: ELISA ; IHC ; IF ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-XPF [XPF 3F2/3]
- Research fields: Genetics
- Clone: XPF 3F2/3
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; IHC ; IF ; WB
- Description: Nucleotide excision repair (NER) is a DNA repair pathway that removes lesions induced by a variety of agents such as UV irradiation. ERCC1 and XPF form the heterodimer ERCC1-XPF, forming a DNA endonuclease that is essential for the dual incision step of NER (cleaves 5' of the DNA lesion).
- Immunogen: A recombinant His-tagged fragment of human XPF protein produced in E. coli
- Isotype: IgG1
- Myeloma used: Sp2/0-Ag14
Target Details
- Target: XPF
- Target background: Nucleotide excision repair (NER) is a DNA repair pathway that removes lesions induced by a variety of agents such as UV irradiation. ERCC1 and XPF form the heterodimer ERCC1-XPF, forming a DNA endonuclease that is essential for the dual incision step of NER (cleaves 5' of the DNA lesion).
Applications
- Application: ELISA ; IHC ; IF ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Dry ice
References
- Facista et al. 2012. Genome Integr. 3(1):3. PMID: 22494821.
- Deficient expression of DNA repair enzymes in early progression to sporadic colon cancer.
- Bhagwat et al. 2009. Cancer Res. 69(17):6831-8. PMID: 19723666.
- Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue.
