Anti-Sm [Y12]

Monoclonal antibody used in quantitative radioimmuno-assays in SLE patients.

Contributors

Institute
Yale University
Cat. #: 155237
Unit size: 100 ug
Research Fields: Immunology
Target: Sm
Host: Mouse
Class: Monoclonal
Product description: Monoclonal antibody used in quantitative radioimmuno-assays in SLE patients. Background and Research Application Sm is an autoantigen on a series of particles composed of RNA and protein. It is one of several nuclear proteins that are found commonly among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Sm is involved in the pathogenesis of Systemic lupus erythematosus (SLE), with antibodies to Sm being found in 20-30% of patients with SLE. This antibody can aid in the titration of autoantibody activity in the sera of SLE patients. Anti-Sm antibody can be used to help understand the role of snRNPs, particularly within disease.
Conjugation: Unconjugated
Isotype: IgG3 kappa
Immunogen: P27048
Immunogen Uniprot ID: P27048
Target background: Monoclonal antibody used in quantitative radioimmuno-assays in SLE patients Background and Research Application Sm is an autoantigen on a series of particles composed of RNA and protein. It is one of several nuclear proteins that are found commonly among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Sm is involved in the pathogenesis of Systemic lupus erythematosus (SLE), with antibodies to Sm being found in 20-30% of patients with SLE. This antibody can aid in the titration of autoantibody activity in the sera of SLE patients. Anti-Sm antibody can be used to help understand the role of snRNPs, particularly within disease.
Format: Liquid
Concentration: 0.9-1.1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: 4° C
Shipping conditions: Dry ice
References:

Lerner et al. 1981. Proc Natl Acad Sci U S A. 78(5):2737-41. PMID: 6789322.

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