The staining pattern of the antibody is located in the nucleus and chromatin.
| Inventor | Institute |
|---|---|
| Stephen West | Cancer Research UK, London Research Institute: Clare Hall Laboratories |
| Cat. #: | 151842 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Genetics;Neurobiology |
| Application: | IP ; WB |
| Target: | Senataxin |
| Reactivity: | Human |
| Clone: | OY11 |
| Host: | Rabbit |
| Class: | Polyclonal |
| Product description: | Defects in Senataxin are the cause of neurodegenerative diseases AOA-2 and ALS4. Senataxin play vital roles in DNA repair and transcription termination. The staining pattern of the antibody is located in the nucleus and chromatin. |
|---|---|
| Conjugation: | Unconjugated |
| Molecular weight: | 303 kDa |
| Immunogen: | A mixture of four peptides corresponding to the following amino acid ranges of human Senataxin: aa8-30, aa884-895, aa1173-1192, aa2654-2677 |
| Target background: | Defects in Senataxin are the cause of neurodegenerative diseases AOA-2 and ALS4. Senataxin play vital roles in DNA repair and transcription termination. The staining pattern of the antibody is located in the nucleus and chromatin. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl. |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Yce et al. 2013. Mol Cell Biol. 33(2):406-17. PMID: 23149945. Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response. |
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