The mAb is specific for mouse S100a9 protein that forms a heterodimer with S100a8 and constitutes 45% of the neutrophil cytosolic protein. The mAb stains neutrophils strongly and monocytes weakly.
| Inventor | Institute |
|---|---|
| Nancy Hogg | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151671 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell signaling and signal transduction;Immunology |
| Application: | IF ; FACS ; IHC ; IF ; IP ; WB |
| Target: | S100a9 |
| Reactivity: | Mouse |
| Clone: | 2B10 |
| Host: | Rat |
| Class: | Monoclonal |
| Product description: | The mAb is specific for mouse S100a9 protein that forms a heterodimer with S100a8 and constitutes 45% of the neutrophil cytosolic protein. The mAb stains neutrophils strongly and monocytes weakly. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Immunogen: | Recombinant full-length murine S100a9 |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | The mAb is specific for mouse S100a9 protein that forms a heterodimer with S100a8 and constitutes 45% of the neutrophil cytosolic protein. The mAb stains neutrophils strongly and monocytes weakly. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Colom et al. 2015. Immunity. 42(6):1075-86. PMID: 26047922. Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo. Chen et al. 2015. Mucosal Immunol. 8(2):390-402. PMID: 25160819. IL-23 activates innate lymphoid cells to promote neonatal intestinal pathology. Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo. Voisin et al. 2010. Am J Pathol. 176(1):482-95. PMID: 20008148. Venular basement membranes ubiquitously express matrix protein low-expression regions: characterization in multiple tissues and remodeling during inflammation. Young et al. 2007. Br J Pharmacol. 151(5):628-37. PMID: 17471175. Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice. Hobbs et al. 2003. Mol Cell Biol. 23(7):2564-76. PMID: 12640137. Myeloid cell function in MRP-14 (S100A9) null mice. |
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