MC5 blocks partial proteolysis of PKC by trypsin in vitro. Fab fragment inhibits phorbol-ester-induced down-regulation of PKC in a rodent gloma cell line.
| Inventor | Institute |
|---|---|
| Peter Parker | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151131 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Tissue-specific biology;Cell signaling and signal transduction |
| Application: | ELISA ; FACS ; IHC ; IF ; IP ; RIA ; WB |
| Target: | Protein Kinase C alpha |
| Reactivity: | Bovine |
| Clone: | MC5 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | CD1c Molecule; CD1C Antigen; C Polypeptide; CD1c Antigen; Differentiation Antigen CD1-Alpha-3; Cortical Thymocyte Antigen; CD1C; BDCA1; CD1A; CD1; R7 |
|---|---|
| Product description: | MC5 blocks partial proteolysis of PKC by trypsin in vitro. Fab fragment inhibits phorbol-ester-induced down-regulation of PKC in a rodent gloma cell line. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Molecular weight: | 80 kDa |
| Immunogen: | Purified bovine brain protein kinase C |
| Myeloma used: | P3X63Ag8 |
| Target background: | Protein Kinase C is a family of serine/threonine protein kinases that are activated by Ca2+, diacylglycerol and membrane phospholipids (phosphatidylserine). |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Kim et al. 2008. Nature. 452(7186):478-82. PMID: 18368118. Molecular identification of a retinal cell type that responds to upward motion. Ng et al. 1999. EMBO J. 18(14):3909-23. PMID: 10406796. PKCalpha regulates beta1 integrin-dependent cell motility through association and control of integrin traffic. Young et al. 1988. Eur J Biochem. 173(1):247-52. PMID: 2451608. A monoclonal antibody recognising the site of limited proteolysis of protein kinase C. Inhibition of down-regulation in vivo. |
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