PCNA, also known as polymerase delta auxiliary protein, is essential for DNA replication and is involved in DNA excision and mismatch repair pathways. PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA is a potentially useful marker of cells with proliferative potential and for identifying […]
| Inventor | Institute |
|---|---|
| David Lane | Cancer Research UK, London Research Institute: Clare Hall Laboratories |
| Cat. #: | 151150 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Other |
| Research Fields: | Cancer;Cell biology;Genetics |
| Application: | IHC ; WB |
| Target: | Proliferating cell nuclear antigen, (PCNA), also known as cyclin or polymerase delta accessory protein |
| Reactivity: | Human ; Insect ; Schizosaccharomyces pombe |
| Clone: | PC5 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Proliferating Cell Nuclear Antigen; DNA Polymerase Delta Auxiliary Protein; ATLD2 |
|---|---|
| Product description: | PCNA, also known as polymerase delta auxiliary protein, is essential for DNA replication and is involved in DNA excision and mismatch repair pathways. PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA is a potentially useful marker of cells with proliferative potential and for identifying the proliferation status of tumour tissue (i.e. relevant to prognosis). |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Immunogen: | Protein A-PCNA fusion obtained from pC2T. |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | PCNA, also known as polymerase delta auxiliary protein, is essential for DNA replication and is involved in DNA excision and mismatch repair pathways. PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA is a potentially useful marker of cells with proliferative potential and for identifying the proliferation status of tumour tissue (i.e. relevant to prognosis). |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Yu et al. 1995. Anal Cell Pathol. 9(1):45-52. PMID: 7577754. Optimization of immunohistochemical staining of proliferating cells in paraffin sections of breast carcinoma using antibodies to proliferating cell nuclear antigen and the Ki-67 antigen. Waseem et al. 1990. J Cell Sci. 96 ( Pt 1):121-9. PMID: 1695635. Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA). Structural conservation and the detection of a nucleolar form. |
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