Monoclonal antibody which detects cytochrome b light chain.
| Inventor | Institute |
|---|---|
| Al Jesaitis | Montana State University |
| Cat. #: | 154138 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Immunology |
| Application: | WB |
| Target: | p22phox |
| Reactivity: | Human |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Monoclonal antibody which detects cytochrome b light chain. Background and Research Application p22phox protein, also known as the human neutrophil cytochrome b light chain (CYBA), is a heterodimeric integral membrane protein which is an essential component of the membrane-associated enzyme phagocyte NADPH-oxidase. Mutations in CYBA gene are known to cause autosomal recessive chronic granulomatous disease that is characterized by the failure of activated phagocytes to generate superoxide. Sp… |
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| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 21 kDa |
| Immunogen: | Partially purified human neutrophil flavocytochrome b |
| Immunogen Uniprot ID: | P13498 |
| Target background: | Monoclonal antibody which detects cytochrome b light chain. Background and Research Application p22phox protein, also known as the human neutrophil cytochrome b light chain (CYBA), is a heterodimeric integral membrane protein which is an essential component of the membrane-associated enzyme phagocyte NADPH-oxidase. Mutations in CYBA gene are known to cause autosomal recessive chronic granulomatous disease that is characterized by the failure of activated phagocytes to generate superoxide. S… |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | Store at -20° C frozen. Avoid repeated freeze / thaw cycles |
| Shipping conditions: | Dry ice |
| References: |
Serwas et al. 2018. Front Immunol. 9:588. PMID: 29651288. Noren Hooten et al. 2012. Arterioscler Thromb Vasc Biol. 32(11):2776-84. PMID: 22982460. Taylor et al. 2007. Methods Mol Biol. 412:429-37. PMID: 18453126. Immunoaffinity purification of human phagocyte flavocytochrome b and analysis of conformational dynamics. Taylor et al. 2004. J Immunol. 173(12):7349-57. PMID: 15585859. Site-specific inhibitors of NADPH oxidase activity and structural probes of flavocytochrome b: character… |
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