Anti-NSun2 [EF-1]

NSun2 is a cytosine-5 RNA methyltransferase of transfer RNAs (tRNAs) and other non-coding RNAs. NSun2 is expressed in various tissues, including skin, brain and testis. Expression of Nsun2 is up-regulated in many tumours.

Contributors

Inventor Institute
Michaela Frye ; Fiona Watt Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Cat. #: 151841
Tool sub type: Primary antibody
Unit size: 100 ug
Cancer types: Breast cancer
Research Fields: Genetics
Application: IF ; IP ; WB
Target: NSun2 (Misu)
Reactivity: Human
Clone: EF-1
Host: Rabbit
Class: Polyclonal
Product description: NSun2 is a cytosine-5 RNA methyltransferase of transfer RNAs (tRNAs) and other non-coding RNAs. NSun2 is expressed in various tissues, including skin, brain and testis. Expression of Nsun2 is up-regulated in many tumours.
Conjugation: Unconjugated
Molecular weight: 80 kDa
Immunogen: NSun2 (Misu) peptides conjugated with keyhole limpet hemocyanin
Immunogen Uniprot ID: N/A
Target background: NSun2 is a cytosine-5 RNA methyltransferase of transfer RNAs (tRNAs) and other non-coding RNAs. NSun2 is expressed in various tissues, including skin, brain and testis. Expression of Nsun2 is up-regulated in many tumours.
Format: Liquid
Concentration: 0.9-1.1 mg/ml
Storage buffer: Whole serum
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Frye et al. 2010. Cancer Lett. 289(1):71-80. PMID: 19740597.

Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer.

Hussain et al. 2009. J Cell Biol. 186(1):27-40. PMID: 19596847.

The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability.

Frye et al. 2006. Curr Biol. 16(10):971-81. PMID: 16713953.

The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors.

Images

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Primary human keratinocytes

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