#151841

Anti-NSun2 [EF-1]

Cat. #151841

Anti-NSun2 [EF-1]

Cat. #: 151841

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 10-12 weeks

Target: NSun2 (Misu)

Class: Polyclonal

Application: IF ; IP ; WB

Reactivity: Human

Host: Rabbit

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Michaela Frye ; Fiona Watt

Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Anti-NSun2 [EF-1]
  • Cancer: Breast cancer
  • Cancers detailed: Breast cancer
  • Research fields: Genetics
  • Clone: EF-1
  • Tool sub type: Primary antibody
  • Class: Polyclonal
  • Conjugation: Unconjugated
  • Molecular weight: 80 kDa
  • Reactivity: Human
  • Host: Rabbit
  • Application: IF ; IP ; WB
  • Description: NSun2 is a cytosine-5 RNA methyltransferase of transfer RNAs (tRNAs) and other non-coding RNAs. NSun2 is expressed in various tissues, including skin, brain and testis. Expression of Nsun2 is up-regulated in many tumours.
  • Immunogen: NSun2 (Misu) peptides conjugated with keyhole limpet hemocyanin
  • Immunogen uniprot id: N/A
  • Recommended controls: Human keratinocytes, human breast cancer cell lines

Target Details

  • Target: NSun2 (Misu)
  • Molecular weight: 80 kDa
  • Tissue cell line specificity: Human keratinocytes, human breast cancer cell lines
  • Target background: NSun2 is a cytosine-5 RNA methyltransferase of transfer RNAs (tRNAs) and other non-coding RNAs. NSun2 is expressed in various tissues, including skin, brain and testis. Expression of Nsun2 is up-regulated in many tumours.

Applications

  • Application: IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: Whole serum
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C

References

  • Frye et al. 2010. Cancer Lett. 289(1):71-80. PMID: 19740597.
  • Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer.
  • Hussain et al. 2009. J Cell Biol. 186(1):27-40. PMID: 19596847.
  • The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability.
  • Frye et al. 2006. Curr Biol. 16(10):971-81. PMID: 16713953.
  • The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors.