NSun2 is a cytosine-5 RNA methyltransferase of transfer RNAs (tRNAs) and other non-coding RNAs. NSun2 is expressed in various tissues, including skin, brain and testis. Expression of Nsun2 is up-regulated in many tumours.
| Inventor | Institute |
|---|---|
| Michaela Frye ; Fiona Watt | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151841 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Breast cancer |
| Research Fields: | Genetics |
| Application: | IF ; IP ; WB |
| Target: | NSun2 (Misu) |
| Reactivity: | Human |
| Clone: | EF-1 |
| Host: | Rabbit |
| Class: | Polyclonal |
| Product description: | NSun2 is a cytosine-5 RNA methyltransferase of transfer RNAs (tRNAs) and other non-coding RNAs. NSun2 is expressed in various tissues, including skin, brain and testis. Expression of Nsun2 is up-regulated in many tumours. |
|---|---|
| Conjugation: | Unconjugated |
| Molecular weight: | 80 kDa |
| Immunogen: | NSun2 (Misu) peptides conjugated with keyhole limpet hemocyanin |
| Immunogen Uniprot ID: | N/A |
| Target background: | NSun2 is a cytosine-5 RNA methyltransferase of transfer RNAs (tRNAs) and other non-coding RNAs. NSun2 is expressed in various tissues, including skin, brain and testis. Expression of Nsun2 is up-regulated in many tumours. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | Whole serum |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Frye et al. 2010. Cancer Lett. 289(1):71-80. PMID: 19740597. Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer. Hussain et al. 2009. J Cell Biol. 186(1):27-40. PMID: 19596847. The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability. Frye et al. 2006. Curr Biol. 16(10):971-81. PMID: 16713953. The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors. |
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