Anti-Nesprin-2 [6C11]

A notable feature of metazoan cells is their morphological plasticity associated with acquisition of a range of complex activities. Implementation of numerous specialized functions during differentiation is dependent upon the rearrangement and transformation of organelles, including the cell nucleus.

Contributors

Institute
A*STAR Accelerate Technologies Pte Ltd
Cat. #: 153482
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Developmental biology;Genetics
Application: IF ; WB
Target: Nesprin-2
Reactivity: Human
Clone: 6C11
Host: Mouse
Class: Monoclonal
Alternate name: Nesp2 antibody, Nesprin-2 antibody, Nuclear envelope spectrin repeat protein 2 antibody
Product description: A notable feature of metazoan cells is their morphological plasticity associated with acquisition of a range of complex activities. Implementation of numerous specialized functions during differentiation is dependent upon the rearrangement and transformation of organelles, including the cell nucleus. Crucial to many cell specific changes in nuclear localization and organization is establishment of connections between the nucleus and cytoskeleton. Such connections are formed in part by KASH-do…
Conjugation: Unconjugated
Isotype: IgG2b kappa
Immunogen: GST fused to residues 6,653-6,835 of human Nesp2
Myeloma used: Sp2/0-Ag14
Target background: A notable feature of metazoan cells is their morphological plasticity associated with acquisition of a range of complex activities. Implementation of numerous specialized functions during differentiation is dependent upon the rearrangement and transformation of organelles, including the cell nucleus. Crucial to many cell specific changes in nuclear localization and organization is establishment of connections between the nucleus and cytoskeleton. Such connections are formed in part by KASH-do…
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice

Images

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HEK293 cells transiently expressing either GFP alone or GFP fused a small Nesp2 isoform (Nesp2a2DKASH) lacking the C-terminal KASH domain. This small isoform contains the ~180 residue Nesp2 polypeptide that was employed in the immunogen. Total cell lysates were analyzed by western blot employing either a rabbit anti-GFP or culture supernatant from three independent anti-Nesp2 hybridoma clones (6C11; 10H8 and 5C3)

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