PR 2D3 reacts with a cell membrane component of cells in the pericrypt sheath; with smooth muscle cells and myofibroblasts. This antibody is considered to be the gold standard for the identification of myofibroblasts.
| Inventor | Institute |
|---|---|
| Walter Bodmer | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151152 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology |
| Application: | IP ; WB ; IHC ; IF |
| Target: | Myofibroblast marker |
| Reactivity: | Human |
| Clone: | PR 2D3 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Proliferating Cell Nuclear Antigen; DNA Polymerase Delta Auxiliary Protein; ATLD2 |
|---|---|
| Product description: | PR 2D3 reacts with a cell membrane component of cells in the pericrypt sheath; with smooth muscle cells and myofibroblasts. This antibody is considered to be the gold standard for the identification of myofibroblasts. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 140 kDa |
| Immunogen: | Crude homogenate of normal colorectal mucosa. |
| Myeloma used: | NS0 |
| Target background: | PR 2D3 reacts with a cell membrane component of cells in the pericrypt sheath; with smooth muscle cells and myofibroblasts. This antibody is considered to be the gold standard for the identification of myofibroblasts. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Hsia et al. 2016. Proc Natl Acad Sci U S A. :. PMID: 27036009. Myofibroblasts are distinguished from activated skin fibroblasts by the expression of AOC3 and other associated markers. Kirkland et al. 2001. J Cell Sci. 114(Pt 11):2055-64. PMID: 11493641. Collagen IV synthesis is restricted to the enteroendocrine pathway during multilineage differentiation of human colorectal epithelial stem cells. Richman et al. 1987. J Clin Pathol. 40(6):593-600. PMID: 3301906. Colonic pericrypt sheath cells: characterisation of cell type with new monoclonal antibody. |
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