#151152

Anti-Myofibroblast marker [PR 2D3]

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Cat. #151152

Anti-Myofibroblast marker [PR 2D3]

Cat. #: 151152

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 1-2 weeks

Target: Myofibroblast marker

Class: Monoclonal

Application: IP ; WB ; IHC ; IF

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Walter Bodmer

Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-Myofibroblast marker [PR 2D3]
  • Alternate name: Proliferating Cell Nuclear Antigen; DNA Polymerase Delta Auxiliary Protein; ATLD2
  • Research fields: Cell biology
  • Clone: PR 2D3
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Molecular weight: 140 kDa
  • Strain: Balb/c
  • Reactivity: Human
  • Host: Mouse
  • Application: IP ; WB ; IHC ; IF
  • Description: PR 2D3 reacts with a cell membrane component of cells in the pericrypt sheath; with smooth muscle cells and myofibroblasts. This antibody is considered to be the gold standard for the identification of myofibroblasts.
  • Immunogen: Crude homogenate of normal colorectal mucosa.
  • Isotype: IgG1
  • Myeloma used: NS0

Target Details

  • Target: Myofibroblast marker
  • Molecular weight: 140 kDa
  • Target background: PR 2D3 reacts with a cell membrane component of cells in the pericrypt sheath; with smooth muscle cells and myofibroblasts. This antibody is considered to be the gold standard for the identification of myofibroblasts.

Applications

  • Application: IP ; WB ; IHC ; IF

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C

References

  • Hsia et al. 2016. Proc Natl Acad Sci U S A. :. PMID: 27036009.
  • Myofibroblasts are distinguished from activated skin fibroblasts by the expression of AOC3 and other associated markers.
  • Kirkland et al. 2001. J Cell Sci. 114(Pt 11):2055-64. PMID: 11493641.
  • Collagen IV synthesis is restricted to the enteroendocrine pathway during multilineage differentiation of human colorectal epithelial stem cells.
  • Richman et al. 1987. J Clin Pathol. 40(6):593-600. PMID: 3301906.
  • Colonic pericrypt sheath cells: characterisation of cell type with new monoclonal antibody.