This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants.
| Inventor | Institute |
|---|---|
| Ron Laskey | University of Cambridge |
| Cat. #: | 153401 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Genetics;Tissue-specific biology |
| Application: | IP ; WB |
| Target: | Xenopus MYB / c-Myb |
| Reactivity: | Human ; Mouse ; Xenopus laevis ; Zebrafish |
| Clone: | 10A3 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | MYB; C-myb_CDS; C-myb8B_CDS; C-myb protein (14 AA); C-myb1A_CDS; C-myb13A_CDS; Efg; Transcriptional activator Myb; C-myb; C-myb14A_CDS; Cmyb; Proto-oncogene c-Myb |
|---|---|
| Product description: | MYB / c-Myb is a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Molecular weight: | 55 kDa |
| Immunogen: | Recombinant v-myb protein |
| Target background: | MYB / c-Myb is a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants. |
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| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Benes et al. 2007. Leuk Res. 31(10):1421-31. PMID: 17624428. Retinoic acid enhances differentiation of v-myb-transformed monoblasts induced by okadaic acid. |
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