Anti-MUS81 [MTA30 2G10/3]

MUS81 and EME1 constitute a heterodimeric endonuclease that has been implicated in mitotic and meiotic recombination in eukaryotes.

Contributors

Inventor Institute
Stephen West Cancer Research UK, London Research Institute: Clare Hall Laboratories
Cat. #: 151291
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Genetics
Application: IF ; ICC ; FACS ; IHC ; IF ; IP ; WB
Target: MUS81
Reactivity: Human
Clone: MTA30 2G10/3
Host: Mouse
Class: Monoclonal
Product description: MUS81 and EME1 constitute a heterodimeric endonuclease that has been implicated in mitotic and meiotic recombination in eukaryotes.
Conjugation: Unconjugated
Isotype: IgG2a
Molecular weight: 60-65 kDa
Immunogen: Human MUS81
Myeloma used: Sp2/0-Ag14
Target background: MUS81 and EME1 constitute a heterodimeric endonuclease that has been implicated in mitotic and meiotic recombination in eukaryotes.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Xu et al. 2019. Sci Adv. 5(10):eaax6366. PMID: 31633027.

Panier et al. 2019. Mol Cell. 76(1):27-43.e11. PMID: 31447390.

Mason et al. 2019. Nat Commun. 10(1):4410. PMID: 31562309.

Xu et al. 2017. Elife. 6:. PMID: 29106372.

Moder et al. 2017. Nat Commun. 8(1):1238. PMID: 29089570.

Lemaon et al. 2017. Nat Commun. 8(1):860. PMID: 29038425.

Li et al. 2017. Mol Med Rep. 16(4):5321-5325. PMID: 28849153.

Dungrawala et al. 2017. Mol Cell. 67(3):374-386.e5. PMID: 28735897.

Di Marco et al. 2017. Mol Cell. 66(5):658-671.e8. PMID: 28575661.

Lv et al. 2017. Tumour Biol. 39(3):1010428317694307. PMID: 28347251.

Wyatt et al. 2017. Mol Cell. 65(5):848-860.e11. PMID: 28257701.

Meisenberg et al. 2017. Nucleic Acids Res. 45(3):1159-1176. PMID: 28180300.

Meisenberg et al. 2017. Nucleic Acids Res. 45(3):1159-1176. PMID: 28180300.

Jo et al. 2016. PLoS Genet. 12(12):e1006465. PMID: 27906959.

Pepe et al. 2014. Nucleic Acids Res. 42(6):3833-45. PMID: 24371268.

CtIP is required to initiate replication-dependent interstrand crosslink repair.

Duquette et al. 2012. PLoS Genet. 8(11):e1003050. PMID: 23144634.

Svendsen et al. 2009. Cell. 138(1):63-77. PMID: 19596235.

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.

Franchitto et al. 2008. J Cell Biol. 183(2):241-52. PMID: 18852298.

Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway.

Images

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Adapted from Duquette et al. 2012. PLoS Genet. 8(11)

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