Anti-MTBP [2C1E11]

MTBP is an MDM2 binding protein that alters p53/MDM2 homeostasis and may contribute to metastatic suppression. Recent studies have demonstrated that loss of MTBP expression in samples that are p53 positive and have low MDM2 is significantly associated with reduced patient survival in Squamous cell carcinoma of the head and neck (SCCHN).

Contributors

Inventor Institute
Mark Boyd University of Liverpool
Cat. #: 151708
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Cell biology;Genetics
Application: WB
Target: MTBP
Reactivity: Human
Clone: 2C1E11
Host: Mouse
Class: Monoclonal
Alternate name: MDM2 Binding Protein, MDM2 (Mouse Double Minute 2)-Binding Protein, Mdm2, Transformed 3T3 Cell Double Minute 2, P53 Binding Protein (Mouse) Binding Protein, Mdm2, Transformed 3T3 Cell Double Minute 2, P53 Binding Protein Binding Protein, MDM2BP, HMTBP
Product description: MTBP is an MDM2 binding protein that alters p53/MDM2 homeostasis and may contribute to metastatic suppression. Recent studies have demonstrated that loss of MTBP expression in samples that are p53 positive and have low MDM2 is significantly associated with reduced patient survival in Squamous cell carcinoma of the head and neck (SCCHN).
Conjugation: Unconjugated
Isotype: IgG1 kappa
Immunogen: Recombinant full-length human MTBP
Target background: MTBP is an MDM2 binding protein that alters p53/MDM2 homeostasis and may contribute to metastatic suppression. Recent studies have demonstrated that loss of MTBP expression in samples that are p53 positive and have low MDM2 is significantly associated with reduced patient survival in Squamous cell carcinoma of the head and neck (SCCHN).
Format: Liquid
Concentration: 1.1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Vlatkovic et al. 2011. Cancer. 117(13):2939-50. PMID: 21692053.

Loss of MTBP expression is associated with reduced survival in a biomarker-defined subset of patients with squamous cell carcinoma of the head and neck.

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