Monoclonal antibody for Maspin (SERPINB5) recognizing both native and denatured forms forms of Maspin.
| Inventor | Institute |
|---|---|
| Phillip Bird | Monash University |
| Cat. #: | 161584 |
|---|---|
| Tool sub type: | Primary antibody |
| Cancer types: | Breast cancer;Genitourinary cancer |
| Research Fields: | Cancer |
| Application: | WB, IF, IP, IHC |
| Target: | SERPINB5, Maspin |
| Reactivity: | Human |
| Clone: | 16F7 |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Teoh SSY et al. 2012. Hybridoma. 31(5):333-9. PMC3482377. |
| Alternate name: | Anti-SERPINB5 |
|---|---|
| Product description: | Maspin is a SERPIN family protein and has been associated with the inhibition of tumor growth and invasion. As of yet, the function of Maspin is unclear. This mouse monoclonal antibody recognizes human Maspin protein in its native and denatured forms, compared to other commercially available antibodies which do not recognize Maspin's denatured form. This antibody can be used in a more expansive range of analytical techniques to study its function and may be helpful in identifying other protei… |
| Isotype: | IgG2a |
| Molecular weight: | 42 kDa |
| Immunogen: | full length recombinant Maspin |
| Target background: | Maspin is a member of the serine protease inhibitor family (Serpins) and is encoded by SERPINB4. It is a 42 kDa, non-inhibitory protein. It is proposed as a tumor suppressor gene and has been suggested to inhibit tumor growth and migration, although this is controversial. Maspin expression has been found to correlate with prognosis for breast and prostate cancers. |
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| Storage buffer: | PBS with 0.02% sodium azide |
|---|---|
| Storage conditions: | Long term store at -20° C. Short term store at 4° C |
| Shipping conditions: | Dry ice |
| References: |
Teoh SSY et al. 2012. Hybridoma. 31(5):333-9. PMC3482377. |
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